Concentration of Selected Macronutrients and Toxic Elements in the Blood in Relation to Pain Severity and Hydrogen Magnetic Resonance Spectroscopy in People with Osteoarthritis of the Spine

Marta Jakoniuk (), Jan Kochanowicz, Agnieszka Lankau, Marianna Wilkiel and Katarzyna Socha
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Marta Jakoniuk: Department of Invasive Neurology, Medical University of Białystok, M. Skłodowskiej-Curie 24a Street, 15-276 Białystok, Poland
Jan Kochanowicz: Department of Neurology, Medical University of Białystok, M. Skłodowskiej-Curie 24a Street, 15-276 Białystok, Poland
Agnieszka Lankau: Department of Integrated Medical Care, Medical University of Białystok, M. Skłodowskiej-Curie 7A Street, 15-096 Białystok, Poland
Marianna Wilkiel: Department of Neurology, Medical University of Białystok, M. Skłodowskiej-Curie 24a Street, 15-276 Białystok, Poland
Katarzyna Socha: Department of Bromatology, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, Poland

IJERPH, 2022, vol. 19, issue 18, 1-15

Abstract: Macronutrients and toxic elements may play an important role in the pathogenesis of osteoarthritis of the spine. The objective of this study was to evaluate the relationship between the concentrations of Ca, Mg, Pb, Cd and Hg in blood with the results of hydrogen magnetic resonance spectroscopy and the severity of pain. Patients with osteoarthritis of the spine (n = 90) and control subjects ( n = 40) were studied. The concentrations of mineral components in blood were determined by atomic absorption spectrometry (ASA). Spinal pain severity was assessed using the Visual Analog Scale (VAS). Hydrogen magnetic resonance spectroscopy ( 1 H-MRS) was used to determine the fat/water ratio in the bodies of L1, L5 and the L4/5 intervertebral disc. The median concentration of Mg in the serum of subjects with spinal degenerative disease was significantly lower ( p < 0.001) than that in healthy subjects. The median concentration of Cd in the blood of subjects with osteoarthritis of the spine was significantly higher ( p < 0.05) than that in the control group. Significantly lower ( p < 0.05) median molar ratios of Ca to Cd and Pb as well as Mg to Pb and Cd were observed among patients with osteoarthritis of the spine. Significant differences ( p < 0.05) were observed in the value of the fat/water ratio in selected spinal structures, depending on normal or abnormal serum Ca and Mg concentrations. The study showed some abnormal macronutrient concentrations, as well as disturbed ratios of beneficial elements to toxic elements in the blood of people with osteoarthritis of the spine.

Keywords: macronutrients; toxic elements; calcium; magnesium; lead; cadmium; mercury; degenerative spine disease; hydrogen magnetic resonance spectroscopy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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