Impact of Impulsivity, Hyperactivity, and Inattention on Discontinuation Rate among Opioid-Dependent Patients Treated with Extended-Release Naltrexone

Ann Tarja Karlsson (), John-Kåre Vederhus, Thomas Clausen, Bente Weimand, Kristin Klemmetsby Solli and Lars Tanum
Additional contact information
Ann Tarja Karlsson: Addiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway
John-Kåre Vederhus: Addiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway
Thomas Clausen: Addiction Unit, Sørlandet Hospital HF, 4604 Kristiansand, Norway
Bente Weimand: Center for Mental Health and Substance Abuse, University of South-Eastern Norway, 3040 Drammen, Norway
Kristin Klemmetsby Solli: Norwegian Centre for Addiction Research, University of Oslo, 0315 Oslo, Norway
Lars Tanum: Department of R&D in Psychiatric Health Care, Akershus University Hospital, 1478 Oslo, Norway

IJERPH, 2022, vol. 19, issue 18, 1-8

Abstract: Previous studies have indicated elevated levels of impulsivity, hyperactivity, and inattention (IHI) among opioid-dependent patients seeking outpatient treatment with extended-release naltrexone (XR-NTX). This led us to hypothesize that IHI may be associated with a higher discontinuation rate for XR-NTX treatment. In a group of 162 patients with opioid dependence, discontinuation prior to the full 24 weeks of the study period (six injections and attending the study visit at 24 weeks) occurred in 49% of the patients, primarily in the early stage of treatment. IHI above the clinical cut-off on the adult ADHD self-report scale (ASRS) was not associated with a risk of premature discontinuation. This finding was not altered when controlling for socio-demographics, substance, use and mental health severity. Conclusively, high levels of IHI per se is not contradictive for XR-NTX treatment in regard to concern for premature discontinuation.

Keywords: extended-release naltrexone; retention in treatment; impulsivity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/18/11435/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/18/11435/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:18:p:11435-:d:912324

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().