Atypical Hemolytic Uremic Syndrome after SARS-CoV-2 Infection: Report of Two Cases

Iwona Smarz-Widelska, Małgorzata Syroka-Główka, Joanna Janowska-Jaremek, Małgorzata M. Kozioł () and Wojciech Załuska
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Iwona Smarz-Widelska: Department of Nephrology, Cardinal Stefan Wyszynski Provincial Hospital, 20-718 Lublin, Poland
Małgorzata Syroka-Główka: Department of Nephrology, Cardinal Stefan Wyszynski Provincial Hospital, 20-718 Lublin, Poland
Joanna Janowska-Jaremek: Department of Nephrology, Cardinal Stefan Wyszynski Provincial Hospital, 20-718 Lublin, Poland
Małgorzata M. Kozioł: Chair and Department of Medical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland
Wojciech Załuska: Department of Nephrology, Medical University of Lublin, 20-954 Lublin, Poland

IJERPH, 2022, vol. 19, issue 18, 1-6

Abstract: Atypical hemolytic uremic syndrome (aHUS) is a life-threatening disease causing systemic thrombotic microangiopathy (TMA) due to the fact of complement dysregulation. Immune activation by viruses, including SARS-CoV-2, can lead to the development of an episode of aHUS against a background of genetic dysregulation in the complement pathway. This paper presents an analysis of two cases of aHUS—siblings diagnosed with familial disease, with a genetic predisposition to aHUS, in whom infection with SARS-CoV-2 was a strong trigger of disease recurrence. The quick recognition and treatment with eculizumab in the early stage of the disease resulted in a rapid improvement in clinical conditions and laboratory parameters.

Keywords: aHUS; TMA; eculizumab; COVID-19 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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