Long-Term Effects of Ambient Particulate and Gaseous Pollutants on Serum High-Sensitivity C-Reactive Protein Levels: A Cross-Sectional Study Using KoGES-HEXA Data

Ji Hyun Kim, Hae Dong Woo, Sunho Choi, Dae Sub Song, Jung Hyun Lee and Kyoungho Lee ()
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Ji Hyun Kim: Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 200 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Korea
Hae Dong Woo: Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 200 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Korea
Sunho Choi: Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 200 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Korea
Dae Sub Song: Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 200 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Korea
Jung Hyun Lee: Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 200 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Korea
Kyoungho Lee: Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, 200 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28160, Korea

IJERPH, 2022, vol. 19, issue 18, 1-19

Abstract: Ambient air pollutants reportedly increase inflammatory responses associated with multiple chronic diseases. We investigated the effects of long-term exposure to ambient air pollution on high-sensitivity C-reactive protein (hs-CRP) using data from 60,581 participants enrolled in the Korean Genome and Epidemiology Study-Health Examinees Study between 2012 and 2017. Community Multiscale Air Quality System with surface data assimilation was used to estimate the participants’ exposure to criteria air pollutants based on geocoded residential addresses. Long-term exposure was defined as the 2-year moving average concentrations of PM 10 , PM 2.5 , SO 2 , NO 2 , and O 3 . Multivariable linear and logistic regression models were utilized to estimate the percent changes in hs-CRP and odds ratios of systemic low-grade inflammation (hs-CRP > 3 mg/L) per interquartile range increment in air pollutants. We identified positive associations between hs-CRP and PM 10 (% changes: 3.75 [95% CI 2.68, 4.82]), PM 2.5 (3.68, [2.57, 4.81]), SO 2 (1.79, [1.10, 2.48]), and NO 2 (3.31, [2.12, 4.52]), while negative association was demonstrated for O 3 (−3.81, [−4.96, −2.65]). Elevated risks of low-grade inflammation were associated with PM 10 (odds ratio: 1.07 [95% CI 1.01, 1.13]), PM 2.5 (1.08 [1.02, 1.14]), and SO 2 (1.05 [1.01, 1.08]). The odds ratios reported indicated that the exposures might be risk factors for inflammatory conditions; however, they did not reflect strong associations. Our findings suggest that exposure to air pollutants may play a role in the inflammation process.

Keywords: ambient air pollution; particulate matter; gaseous pollutant; long-term exposure; high-sensitivity C-reactive protein; systemic low-grade inflammation; cross-sectional study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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