Radical Hysterectomy for Early Stage Cervical Cancer

Giorgio Bogani (), Violante Di Donato, Giovanni Scambia, Francesco Raspagliesi, Vito Chiantera, Giulio Sozzi, Tullio Golia D’Augè, Ludovico Muzii, Pierluigi Benedetti Panici, Ottavia D’Oria, Enrico Vizza, Andrea Giannini and on behalf of The Investigators of the Italian Gynecological Cancer Study Group
Additional contact information
Giorgio Bogani: Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy
Violante Di Donato: Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy
Giovanni Scambia: Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00182 Rome, Italy
Francesco Raspagliesi: Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy
Vito Chiantera: Department of Gynecologic Oncology, University of Palermo, 90127 Palermo, Italy
Giulio Sozzi: Department of Gynecologic Oncology, University of Palermo, 90127 Palermo, Italy
Tullio Golia D’Augè: Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy
Ludovico Muzii: Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy
Pierluigi Benedetti Panici: Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy
Ottavia D’Oria: Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy
Enrico Vizza: Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS “Regina Elena” National Cancer Institute, 00144 Rome, Italy
Andrea Giannini: Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, 00185 Rome, Italy
on behalf of The Investigators of the Italian Gynecological Cancer Study Group: Members of The Investigators of the Italian Gynecological Cancer Study Group present in Acknowledgments section.

IJERPH, 2022, vol. 19, issue 18, 1-7

Abstract: Radical hysterectomy and plus pelvic node dissection are the primary methods of treatment for patients with early stage cervical cancer. During the last decade, growing evidence has supported the adoption of a minimally invasive approach. Retrospective data suggested that minimally invasive surgery improves perioperative outcomes, without neglecting long-term oncologic outcomes. In 2018, the guidelines from the European Society of Gynaecological Oncology stated that a “minimally invasive approach is favored” in comparison with open surgery. However, the phase III, randomized Laparoscopic Approach to Cervical Cancer (LACC) trial questioned the safety of the minimally invasive approach. The LACC trial highlighted that the execution of minimally invasive radical hysterectomy correlates with an increased risk of recurrence and death. After its publication, other retrospective studies investigated this issue, with differing results. Recent evidence suggested that robotic-assisted surgery is not associated with an increased risk of worse oncologic outcomes. The phase III randomized Robotic-assisted Approach to Cervical Cancer (RACC) and the Robotic Versus Open Hysterectomy Surgery in Cervix Cancer (ROCC) trials will clarify the pros and cons of performing a robotic-assisted radical hysterectomy (with tumor containment before colpotomy) in early stage cervical cancer.

Keywords: cervical cancer; LACC; laparoscopy; robotic; radical hysterectomy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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