Difficult Therapeutic Decisions in Gorham-Stout Disease–Case Report and Review of the Literature

Katarzyna Wojciechowska-Durczynska, Arkadiusz Zygmunt, Marta Mikulak, Marta Ludwisiak and Andrzej Lewinski ()
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Katarzyna Wojciechowska-Durczynska: Department of Endocrinology and Metabolic Disease, Medical University of Lodz, 93-338 Lodz, Poland
Arkadiusz Zygmunt: Department of Endocrinology and Metabolic Disease, Medical University of Lodz, 93-338 Lodz, Poland
Marta Mikulak: Department of Endocrinology and Metabolic Disease, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Lodz, Poland
Marta Ludwisiak: Department of Endocrinology and Metabolic Disease, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Lodz, Poland
Andrzej Lewinski: Department of Endocrinology and Metabolic Disease, Medical University of Lodz, 93-338 Lodz, Poland

IJERPH, 2022, vol. 19, issue 18, 1-8

Abstract: Gorham-Stout disease (GSD) is a very rare, life-threatening condition characterized by the proliferation of lymphatic vessels and osteolysis. Unfortunately, no standard treatment has been determined for management of GSD. The available therapies are not equally effective and carry substantial side-effects. We report a 42-year-old female with GSD manifested in multifocal osteolysis and chronic chylothorax and ascites. The combined treatment with sirolimus and zoledronic acid due to its synergism of action was introduced. To our knowledge, this is the first Polish case report of adult patients with Gorham-Stout disease.

Keywords: osteolysis; lymphogenesis; zoledronic acid; sirolimus; therapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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