Hysteroscopic Resection Followed by Adjuvant Radiotherapy: Report of a New Therapeutic Approach to Primary Cervical Diffuse Large B-Cell Lymphoma

Guglielmo Stabile (), Lara Sancin, Pierino Boschian Bailo, Chiara Ripepi, Andrea Romano, Stefania Carlucci and Giuseppe Ricci
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Guglielmo Stabile: Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Department of Obstetrics and Gynaecology, 34137 Trieste, Italy
Lara Sancin: Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy
Pierino Boschian Bailo: Department of Obstetrics and Gynecology, Azienda Sanitaria Universitaria Giuliano-Isontina, San Polo Hospital, Gorizia-Monfalcone, 34149 Trieste, Italy
Chiara Ripepi: Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy
Andrea Romano: Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy
Stefania Carlucci: Department of Obstetrics and Gynecology, Azienda Sanitaria Universitaria Giuliano-Isontina, San Polo Hospital, Gorizia-Monfalcone, 34149 Trieste, Italy
Giuseppe Ricci: Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Department of Obstetrics and Gynaecology, 34137 Trieste, Italy

IJERPH, 2022, vol. 19, issue 18, 1-7

Abstract: The female genital tract can be involved as a secondary manifestation of disseminated lymphomas or leukemia but can rarely be the primary site of so-called extranodal lymphomas. Primary lymphomas of the female genital tract can affect the uterine corpus, uterine cervix, vulva, vagina or adnexa. Only about 0.008% of all cervical tumors are primary malignant lymphomas. The presenting symptoms are unspecific and also refer to much more common diseases of the female genital tract. Cervical cytology is usually negative. Preoperative diagnosis requires deep cervical biopsy. To date there is no consensus regarding optimal treatment. Radiotherapy, chemotherapy and surgery are used in different association. We report the first case reported in literature managed with an urgent hysteroscopic resection of a primary cervical diffuse large B-cell lymphoma, followed by adjuvant radiotherapy. Relevant literature was reviewed. Our conservative approach needs to be validated in the future, especially for women with pregnancy desire and for those with low performance status. To date, after 24 months from diagnosis, our patient is still disease-free.

Keywords: cervical cancer; lymphoma; hysteroscopy; conservative treatment; minimally invasive approach (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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