Home Environment in Early-Life and Lifestyle Factors Associated with Asthma and Allergic Diseases among Inner-City Children from the REPRO_PL Birth Cohort

Katarzyna Kapszewicz, Daniela Podlecka, Kinga Polańska, Iwona Stelmach, Pawel Majak, Barbara Majkowska-Wojciechowska, Bogusław Tymoniuk, Joanna Jerzyńska () and Agnieszka Brzozowska
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Katarzyna Kapszewicz: Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland
Daniela Podlecka: Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland
Kinga Polańska: Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland
Iwona Stelmach: Poddębice Health Center, 99-200 Poddębice, Poland
Pawel Majak: Department of Pediatric Pulmonology, Copernicus Memorial Hospital, Medical University of Lodz, 93-513 Lodz, Poland
Barbara Majkowska-Wojciechowska: Department of Immunology and Allergy, Medical University of Lodz, 93-513 Lodz, Poland
Bogusław Tymoniuk: Department of Immunology and Allergy, Medical University of Lodz, 93-513 Lodz, Poland
Joanna Jerzyńska: Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland
Agnieszka Brzozowska: Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland

IJERPH, 2022, vol. 19, issue 19, 1-13

Abstract: Objective. We hypothesized that, in our REPRO_PL cohort, exposure to indoor allergens and lifestyle factors in early life are associated with risk of asthma, atopic dermatitis, and allergic rhinitis at ten years of age. Methods. We only examined children who had lived in the same house from birth. Children’s exposure to tobacco smoke was assessed based on cotinine levels in urine. House dust samples were collected. Results. Higher Fel d1 concentration in house dust was associated with significantly higher risk of developing asthma at age 10 years (95% CI,10.87 to 20.93; p < 0.001). Frequent house cleaning was associated with development of atopic dermatitis (odds ratio 0.61; 95% CI 0.37 to 0.99; p = 0.045). Clustering of exposure to HDM revealed two types of environment. Cluster 1, defined as lower HDM (dust), in contrast to Cluster 2, defined as higher HDM, was characterized by old-type windows, lower fungus and dampness levels, as well as more frequent house cleaning. Conclusion. Exposure to cat allergens and new-type buildings that limit air flow while increasing the condensation of steam on the windows and thereby stimulating the growth of fungi are risk factors for the development of asthma.

Keywords: HDM allergy; asthma; children; atopic dermatitis; allergic rhinitis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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