The Bright Side of Skin Autofluorescence Determination in Children and Adolescents with Newly Diagnosed Type 1 Diabetes Mellitus: A Potential Predictor of Remission?

Kristina Podolakova, Lubomir Barak, Emilia Jancova, Juraj Stanik, Katarina Sebekova and Ludmila Podracka ()
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Kristina Podolakova: Department of Pediatrics, Medical Faculty of Comenius University and National Institute for Children’s Diseases, Limbova 1, 83340 Bratislava, Slovakia
Lubomir Barak: Department of Pediatrics, Medical Faculty of Comenius University and National Institute for Children’s Diseases, Limbova 1, 83340 Bratislava, Slovakia
Emilia Jancova: Department of Pediatrics, Medical Faculty of Comenius University and National Institute for Children’s Diseases, Limbova 1, 83340 Bratislava, Slovakia
Juraj Stanik: Department of Pediatrics, Medical Faculty of Comenius University and National Institute for Children’s Diseases, Limbova 1, 83340 Bratislava, Slovakia
Katarina Sebekova: Institute of Molecular Biomedicine, Medical Faculty of Comenius University, Sasinkova 4, 81108 Bratislava, Slovakia
Ludmila Podracka: Department of Pediatrics, Medical Faculty of Comenius University and National Institute for Children’s Diseases, Limbova 1, 83340 Bratislava, Slovakia

IJERPH, 2022, vol. 19, issue 19, 1-13

Abstract: Skin autofluorescence (SAF) is a noninvasive method reflecting tissue accumulation of advanced glycation end products (AGEs). We investigated whether, in newly diagnosed children and adolescents with type 1 diabetes (T1D), this surrogate marker of long-term glycemia is associated with markers of the early manifestation phase, residual secretion capacity of the ß-cells, and the occurrence of remission. SAF was measured in 114 children and adolescents (age: 8.0 ± 4.5 years, 44% girls) at the time of T1D diagnosis, and related to HbA1c, C-peptide, diabetic ketoacidosis, and remission. 56 patients were followed up for 1 year. Seventy-four sex- and age-matched healthy individuals served as controls. SAF was higher in the T1D group compared with controls (1.0 ± 0.2 vs. 0.9 ± 0.2, p < 0.001). At the time of diagnosis, SAF correlated with HbA1c (r = 0.285, p = 0.002), was similar in patients with and without ketoacidosis, and was lower in the remitters compared with non-remitters (0.95 ± 0.18 vs. 1.04 ± 0.26, p = 0.027). Unlike HbA1c, SAF was an independent predictor of remission (∆R 2 = 0.051, p = 0.004). Former studies consider SAF in diabetic patients as a tool to identify individuals at an increased risk of chronic complications. Here we show that determination of SAF at the time of T1D diagnosis might potentially predict remission, at least in children.

Keywords: skin autofluorescence; HbA1c; Type 1 diabetes mellitus; children; remission period (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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