Systematic Review of Survival Analysis in Leprosy Studies—Including the Following Outcomes: Relapse, Impairment of Nerve Function, Reactions and Physical Disability

Celivane Cavalcanti Barbosa (), Gilberto Silva Nunes Bezerra, Amanda Tavares Xavier, Maria de Fátima Pessoa Militão de Albuquerque, Cristine Vieira do Bonfim, Zulma Maria de Medeiros and Wayner Vieira de Souza
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Celivane Cavalcanti Barbosa: Department of Collective Health, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife 50740-465, Brazil
Gilberto Silva Nunes Bezerra: PRISM Research Institute, Technological University of the Shannon, Midlands Midwest, N37 HD68 Athlone, Ireland
Amanda Tavares Xavier: Postgraduate Health Sciences, University of Pernambuco, Recife 50100-130, Brazil
Maria de Fátima Pessoa Militão de Albuquerque: Department of Collective Health, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife 50740-465, Brazil
Cristine Vieira do Bonfim: Postgraduate Program in Public Health, Federal University of Pernambuco, Recife 50670-901, Brazil
Zulma Maria de Medeiros: Postgraduate Health Sciences, University of Pernambuco, Recife 50100-130, Brazil
Wayner Vieira de Souza: Department of Collective Health, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife 50740-465, Brazil

IJERPH, 2022, vol. 19, issue 19, 1-24

Abstract: Leprosy is a public health problem in South American, African and Oceanian countries. National programs need to be evaluated, and the survival analysis model can aid in the construction of new indicators. The aim of this study was to assess the period of time until the outcomes of interest for patients with or exposed to leprosy by means of survival analysis surveys. This review researched articles using the databases of PubMed, Science Direct, Scopus, Scielo and BVS published in English and Portuguese. Twenty-eight articles from Brazil, India, Bangladesh, the Philippines and Indonesia were included. The Kaplan–Meier method, which derives the log-rank test, and Cox’s proportional hazards regression, which obtains the hazard ratio, were applied. The mean follow-up until the following outcomes were: (I) leprosy (2.3 years) in the population who were exposed to it, (II) relapse (5.9 years), (III) clinical manifestations before, during and after treatment—nerve function impairment (5.2 years), leprosy reactions (4.9 years) and physical disability (8.3 years) in the population of patients with leprosy. Therefore, the use of survival analysis will enable the evaluation of national leprosy programs and assist in the decision-making process to face public health problems.

Keywords: leprosy; epidemiology; statistical analysis; survival analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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