A Pilot Study on the Concentration, Distribution and Bioaccumulation of Polybrominated Diphenyl Ethers (PBDEs) in Tissues and Organs of Grassland Sheep

Wenming Chen, Xinrui Yang, Junsong Bao, Ziyi Lin, Tianwei Li, Ying Wang, Aiqin Zhang, Jicheng Hu and Jun Jin ()
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Wenming Chen: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Xinrui Yang: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Junsong Bao: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Ziyi Lin: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Tianwei Li: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Ying Wang: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Aiqin Zhang: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Jicheng Hu: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
Jun Jin: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China

IJERPH, 2022, vol. 19, issue 19, 1-13

Abstract: Polybrominated diphenyl ether (PBDE) concentrations in various tissues and organs of grassland sheep from Inner Mongolia, China, were determined. The abilities of PBDEs binding to ovine serum albumin (OSA) and Cytochrome P450 enzyme (CYP3A24) were assessed by fluorescence spectroscopy and molecular docking simulations. The PBDE concentrations in the sheep tissue and organ samples were 33.4–167 pg/g dw. The distribution of PBDEs in sheep organs and tissues is affected not only by the function of organs and tissues, but also by the characteristics of PBDEs. Adipose tissue tends to bioaccumulate more-brominated BDEs (BDE-154, -153, and -183), but muscle tissues and visceral organs mainly bioaccumulate less-brominated BDEs. The distribution of PBDEs in visceral organs is mainly affected by the transport of ovine serum albumin (OSA) and the metabolism of CYP3A24 enzyme. The distribution of PBDEs in adipose tissue and brain is mainly affected by their logK OW .

Keywords: polybrominated diphenyl ethers; tissue distribution; ovine serum albumin; cytochrome P450 enzyme; molecular docking; molecular properties (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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