Increased Risk of Chronic Obstructive Pulmonary Disease in Patients with Hyperlipidemia: A Nationwide Population-Based Cohort Study

Hao-Yu Yang, Li-Yu Hu, Hon-Jhe Chen, Ru-Yih Chen, Chang-Kuo Hu and Cheng-Che Shen ()
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Hao-Yu Yang: Department of Family Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Li-Yu Hu: Department of Psychiatry, Taipei Veterans General Hospital, Taipei 112, Taiwan
Hon-Jhe Chen: Department of Family Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Ru-Yih Chen: Department of Family Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Chang-Kuo Hu: Division of Neurosurgery, Department of Surgery, Chiayi Branch, Taichung Veterans General Hospital, Chiayi 600, Taiwan
Cheng-Che Shen: School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan

IJERPH, 2022, vol. 19, issue 19, 1-11

Abstract: The coexistence of chronic obstructive pulmonary disease (COPD) and cardiovascular disease is common and causes poor prognoses. Hyperlipidemia is the most common risk factor for cardiovascular disease, but the association between hyperlipidemia and COPD remains ambiguous. This study aimed to investigate the risk of COPD development in patients with hyperlipidemia. This retrospective cohort study used information from the National Health Insurance Research Database in Taiwan. We enrolled 21,790 patients with hyperlipidemia and 87,160 control patients without hyperlipidemia for comparison, with a follow-up period of over 10 years. The incidence of new-onset COPD was higher in patients with hyperlipidemia (36.14 per 1000 person-years) than in the controls (22.29 per 1000 person-years). Patients with hyperlipidemia were 1.48 times more likely to develop subsequent COPD than the controls without hyperlipidemia (95% confidence interval 1.44 to 1.53, p < 0.001) following adjustments for age, sex, and comorbidities. In addition, nephropathy, hypertension, congestive heart failure, age, and sex (female) were potential risk factors for developing COPD in patients with hyperlipidemia. Patients with hyperlipidemia may have an increased risk of developing COPD.

Keywords: epidemiology; hyperlipidemia; chronic obstructive pulmonary disease (COPD); risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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