Anabaenopeptins from Nostoc edaphicum CCNP1411

Robert Konkel, Michał Grabski, Marta Cegłowska, Ewa Wieczerzak, Grzegorz Węgrzyn and Hanna Mazur-Marzec ()
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Robert Konkel: Division of Marine Biotechnology, Institute of Oceanography, University of Gdańsk, M. J. Piłsudskiego 46, PL-81378 Gdynia, Poland
Michał Grabski: Department of Molecular Biology, University of Gdansk, Wita Stwosza 59, PL-80308 Gdańsk, Poland
Marta Cegłowska: Institute of Oceanology, Polish Academy of Sciences, Powstańców Warszawy 55, PL-81712 Sopot, Poland
Ewa Wieczerzak: Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, PL-80308 Gdańsk, Poland
Grzegorz Węgrzyn: Department of Molecular Biology, University of Gdansk, Wita Stwosza 59, PL-80308 Gdańsk, Poland
Hanna Mazur-Marzec: Division of Marine Biotechnology, Institute of Oceanography, University of Gdańsk, M. J. Piłsudskiego 46, PL-81378 Gdynia, Poland

IJERPH, 2022, vol. 19, issue 19, 1-15

Abstract: Cyanobacteria of the Nostoc genus belong to the most prolific sources of bioactive metabolites. In our previous study on Nostoc edaphicum strain CCNP1411, the occurrence of cyanopeptolins and nostocyclopeptides was documented. In the current work, the production of anabaenopeptins (APs) by the strain was studied using genetic and chemical methods. Compatibility between the analysis of the apt gene cluster and the structure of the identified APs was found. Three of the APs, including two new variants, were isolated as pure compounds and tested against four serine proteases and carboxypeptidase A (CPA). The in vitro enzymatic assays showed a typical activity of this class of cyanopeptides, i.e., the most pronounced effects were observed in the case of CPA. The activity of the detected compounds against important metabolic enzymes confirms the pharmaceutical potential of anabaenopeptins.

Keywords: anabaenopeptins; cyanobacteria; apt gene cluster; nonribosomal peptide synthetase; biological activity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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