Estimated Glomerular Filtration Rate and Hearing Impairment in Japan: A Longitudinal Analysis Using Large-Scale Occupational Health Check-Up Data

Hiroshi Miyake, Takehiro Michikawa (), Satsue Nagahama, Keiko Asakura and Yuji Nishiwaki
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Hiroshi Miyake: Department of Environmental and Occupational Health, Toho University Graduate School of Medicine, 5-21-16, Omorinishi, Otaku, Tokyo 143-8540, Japan
Takehiro Michikawa: Department of Environmental and Occupational Health, School of Medicine, Toho University, 5-21-16, Omorinishi, Otaku, Tokyo 143-8540, Japan
Satsue Nagahama: Department of Environmental and Occupational Health, School of Medicine, Toho University, 5-21-16, Omorinishi, Otaku, Tokyo 143-8540, Japan
Keiko Asakura: Department of Environmental and Occupational Health, School of Medicine, Toho University, 5-21-16, Omorinishi, Otaku, Tokyo 143-8540, Japan
Yuji Nishiwaki: Department of Environmental and Occupational Health, School of Medicine, Toho University, 5-21-16, Omorinishi, Otaku, Tokyo 143-8540, Japan

IJERPH, 2022, vol. 19, issue 19, 1-11

Abstract: Several longitudinal studies have examined associations between renal dysfunction and hearing impairment. Here, we explored the longitudinal association between estimated glomerular filtration rate (eGFR) and hearing impairment among the working-age population in Japan. Participants were 88,425 males and 38,722 females aged 20–59 years, without hearing impairment at baseline (2013), who attended Japanese occupational annual health check-ups from 2013 to 2020 fiscal year. eGFR was categorized into four groups (eGFR upper half of ≥90, lower half of ≥90 (reference), 60–89, and <60 mL/min/1.73 m 2 ). Low- and high-frequency hearing impairment were assessed using data from pure-tone audiometric testing. A Cox proportional hazards model was applied to estimate hazard ratio (HR) values for hearing impairment. Low eGFR did not increase the risk of low- or high-frequency hearing impairment. For males, multivariable-adjusted HR of high-frequency hearing impairment was 1.16 (95% confidence interval, 1.01–1.34) for the upper half of the ≥90 mL/min/1.73 m 2 ; however, this positive association between high eGFR and high-frequency hearing impairment did not appear to be robust in a number of sensitivity analyses. We conclude that, among the Japanese working-age population, eGFR was not generally associated with hearing impairment in people of either sex.

Keywords: estimated glomerular filtration rate; follow-up; hearing impairment; occupational health; serum creatinine (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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