Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

Emmanuel A. Ayeni, Ahmad M. Aldossary, Daniel A. Ayejoto, Lanre A. Gbadegesin, Abdullah A. Alshehri, Haya A. Alfassam, Henok K. Afewerky, Fahad A. Almughem, Saidu M. Bello and Essam A. Tawfik ()
Additional contact information
Emmanuel A. Ayeni: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
Ahmad M. Aldossary: National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia
Daniel A. Ayejoto: Department of Industrial Chemistry, University of Ilorin, Ilorin 240003, Nigeria
Lanre A. Gbadegesin: University of Chinese Academy of Sciences, Beijing 100049, China
Abdullah A. Alshehri: National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia
Haya A. Alfassam: KACST-BWH Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia
Henok K. Afewerky: Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
Fahad A. Almughem: National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia
Saidu M. Bello: Institute of Pharmacognosy, University of Szeged, 6720 Szeged, Hungary
Essam A. Tawfik: National Center of Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi Arabia

IJERPH, 2022, vol. 19, issue 19, 1-24

Abstract: Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative diseases (NDDs) increases with age. Neuronal hormones and neurotransmitters are major determinant factors regulating brain structure and functions. The implications of environmental and climatic changes emerged recently as influence factors on numerous diseases. However, the complex interaction of neurotransmitters and neuronal hormones and their depletion under environmental and climatic influences on NDDs are not well established in the literature. In this review, we aim to explore the connection between the environmental and climatic factors to NDDs and to highlight the available and potential therapeutic interventions that could use to improve the quality of life and reduce susceptibility to NDDs.

Keywords: neurodegenerative diseases; hormones; neurotransmitters; environment; climate; public health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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