The Influence of HLA Alleles on the Affective Distress Profile

Mihaela Laura Vică, Cristian Delcea, Gabriela Alina Dumitrel, Mihaela Elvira Vușcan, Horea Vladi Matei (), Cosmin Adrian Teodoru and Costel Vasile Siserman
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Mihaela Laura Vică: Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Cristian Delcea: Institute of Legal Medicine, 400006 Cluj-Napoca, Romania
Gabriela Alina Dumitrel: Faculty of Industrial Chemistry and Environmental Engineering, Polytechnic University, 300223 Timișoara, Romania
Mihaela Elvira Vușcan: Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Horea Vladi Matei: Department of Cellular and Molecular Biology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Cosmin Adrian Teodoru: Clinical Surgical Department, Faculty of Medicine, “Lucian Blaga” University, 550002 Sibiu, Romania
Costel Vasile Siserman: Institute of Legal Medicine, 400006 Cluj-Napoca, Romania

IJERPH, 2022, vol. 19, issue 19, 1-11

Abstract: (1) Background: Affective distress can be triggered by aggressive stimuli with an unfavorable role for the individual. Some of the factors that lead to the development and evolution of a mental disorder can be genetic. The aim of this study is to determine some correlations between the human leukocyte antigen (HLA) genes and the affective distress profile (PDA). (2) Methods: A psychological assessment and testing tool for anxiety was applied to 115 people. The low-resolution HLA alleles of class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1 and HLA-DQB1) were identified by the PCR technique after DNA extraction from the blood. Depending on the PDA, the subjects were divided into two groups: a group with a low PDA and another one with a medium and high PDA. The IBM SPSS software was used to compare the frequency of HLA alleles between the two groups. (3) Results: The univariate analysis revealed a significant association of the HLA-A locus (A*01, A*30), HLA-B (B*08), and HLA-DRB1 (DRB1*11) with the low PDA group and of the HLA-A locus (A*32), HLA-B (B*52), and HLA-C (C*12) with the medium and high PDA group. (4) Conclusions: The present study highlighted potential associations between HLA alleles and anxiety disorders.

Keywords: anxiety; affective distress; HLA; univariate analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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