Nontyphoidal Salmonella Infection Associated with Subsequent Risk of Hematological Malignancies: A Nationwide Population-Based Cohort Study

Chih-Hui Yun, Wei-Chun Kao, Chung Y. Hsu, Renin Chang, Ming-Fang Cheng () and Yao-Min Hung ()
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Chih-Hui Yun: Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Wei-Chun Kao: Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Chung Y. Hsu: Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404328, Taiwan
Renin Chang: Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Ming-Fang Cheng: Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
Yao-Min Hung: School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan

IJERPH, 2022, vol. 19, issue 19, 1-10

Abstract: This study aimed to investigate the relationship between nontyphoidal salmonellosis (NTS) and new-onset hematological malignancy. We conducted a 17-year nationwide, population-based, retrospective cohort study to examine the association between NTS and the risk of hematological malignancies by using the Longitudinal Health Insurance Database (LHID) of Taiwan. Participants were enrolled from 2000 to 2015 and were monitored until 2017. We traced the years 1998–2000 to ensure that the cases included were newly diagnosed with NTS. The NTS cohort included 13,790 patients with newly diagnosed NTS between 2000 and 2015. Each patient was propensity score matched at a 1:4 ratio with people without NTS. Cumulative incidence, hazard ratios (HRs), and 95% confidence intervals (CIs) were calculated after adjusting for age, sex, income, urbanization, and medical comorbidities. The adjusted hazard ratio (aHR) of hematological malignancies for NTS patients relative to those without NTS was 1.42 (95% CI 0.91–2.20). In the age subgroup analysis, NTS had a significantly greater risk of hematological malignancies for patients older than 60 (aHR 3.04, 95% CI 1.46–6.34), with an incidence rate of 11.7 per 10,000 person-years. In patients over 60 years of age, a prominent risk of hematological malignancies was observed at a follow-up of more than 3 years after the index date (aHR 3.93, 95% CI 1.60–9.65). A history of NTS is associated with the risk of subsequent hematological malignancies in Taiwanese subjects older than 60.

Keywords: NTS; nontyphoidal salmonellosis; hematological malignancies; lymphoma; multiple myeloma; leukemia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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