Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica

Mohammad H. Rahbar, Maureen Samms-Vaughan, Yuansong Zhao, Sepideh Saroukhani, Sheikh F. Zaman, Jan Bressler, Manouchehr Hessabi, Megan L. Grove, Sydonnie Shakspeare-Pellington and Katherine A. Loveland
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Mohammad H. Rahbar: Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Maureen Samms-Vaughan: Department of Child & Adolescent Health, Mona Campus, The University of the West Indies (UWI), Kingston 7, Jamaica
Yuansong Zhao: Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Sepideh Saroukhani: Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Sheikh F. Zaman: Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Jan Bressler: Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Manouchehr Hessabi: Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Megan L. Grove: Department of Epidemiology, Human Genetics and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Sydonnie Shakspeare-Pellington: Department of Child & Adolescent Health, Mona Campus, The University of the West Indies (UWI), Kingston 7, Jamaica
Katherine A. Loveland: “Louis A Faillace, MD”, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA

IJERPH, 2022, vol. 19, issue 1, 1-19

Abstract: Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, glutathione S-transferase (GST) genes, including GSTT1 , GSTP1 , and GSTM1, play an important role in the metabolism of xenobiotics including As in humans. Using data from 375 typically developing children (2–8 years) in Jamaica, we investigated the environmental and sociodemographic factors, as well as their possible interactions with the children’s genotype for GST genes in relation to having a detectable level of blood As concentration (i.e., >1.3 μg/L). Using multivariable logistic regression, we have identified environmental factors significantly associated with blood As concentrations that include a child’s age, parental education levels, and the consumption of saltwater fish, cabbage, broad beans, and avocado (all p < 0.01). Based on the multivariable analysis including gene x environment interactions, we found that among children with the Ile/Ile genotype for GSTP1 Ile105Val, children who consumed avocado had higher odds of having a detectable blood As concentration compared to children who did not eat avocado.

Keywords: children; blood arsenic concentrations; glutathione S-transferase (GST) genes; food consumption; interaction; Jamaica (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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