Exposure to Nickel Oxide Nanoparticles Induces Acute and Chronic Inflammatory Responses in Rat Lungs and Perturbs the Lung Microbiome

Mi-Jin Jeong, Soyeon Jeon, Hak-Sun Yu, Wan-Seob Cho, Seungho Lee, Dongmug Kang, Youngki Kim, Yoon-Ji Kim and Se-Yeong Kim
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Mi-Jin Jeong: Department of Parasitology and Tropical Medicine, Medical College, Pusan National University, Yangsan 50612, Korea
Soyeon Jeon: Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Korea
Hak-Sun Yu: Department of Parasitology and Tropical Medicine, Medical College, Pusan National University, Yangsan 50612, Korea
Wan-Seob Cho: Lab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Korea
Seungho Lee: Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea
Dongmug Kang: Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea
Youngki Kim: Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea
Yoon-Ji Kim: Environmental Health Center of Asbestos, Pusan National University Yangsan Hospital, Yangsan 50612, Korea
Se-Yeong Kim: Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea

IJERPH, 2022, vol. 19, issue 1, 1-16

Abstract: Nickel oxide nanoparticles (NiO NPs) are highly redox active nanoparticles. They can cause acute and chronic inflammation in rat lungs. Unlike the gut microbiome, the association between the lung microbiome’s role and pulmonary inflammatory response to inhaled nanoparticles remains largely unexplored. We aimed to explore the interaction between the lung microbiome and inflammatory responses in rats exposed to NiO NPs. Thirty female Wistar rats were randomly categorized into control and low- (50 cm 2 /rat), and high- (150 cm 2 /rat) dose NiO NPs exposure groups. NiO NPs were intratracheally instilled, and cytological, biochemical, proinflammatory cytokine, and lung microbiome analyses of bronchoalveolar lavage fluid were performed at 1 day and 4 weeks after instillation. NiO NPs caused a neutrophilic and lymphocytic inflammatory response in rat lung. We demonstrated that exposure to NiO NPs can alter the lung microbial composition in rats. In particular, we found that more Burkholderiales are present in the NiO NPs exposure groups than in the control group at 1 day after instillation. Dysbiosis in the lung microbiome is thought to be associated with acute lung inflammation. We also suggested that Burkholderiales may be a key biomarker associated with lung neutrophilic inflammation after NiO NPs exposure.

Keywords: nickel oxide nanoparticles; lung microbiome; inflammatory response (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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