Hypothesizing in the Face of the Opioid Crisis Coupling Genetic Addiction Risk Severity (GARS) Testing with Electrotherapeutic Nonopioid Modalities Such as H-Wave Could Attenuate Both Pain and Hedonic Addictive Behaviors

Ashim Gupta, Abdalla Bowirrat, Luis Llanos Gomez, David Baron, Igor Elman, John Giordano, Rehan Jalali, Rajendra D. Badgaiyan, Edward J. Modestino, Mark S. Gold, Eric R. Braverman, Anish Bajaj and Kenneth Blum
Additional contact information
Ashim Gupta: Future Biologics, Lawrenceville, GA 30043, USA
Abdalla Bowirrat: Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel
Luis Llanos Gomez: The Kenneth Blum Behavioral & Neurogenetic Institute, Austin, TX 78701, USA
David Baron: Graduate College, Western University Health Sciences, Pomona, CA 91766, USA
Igor Elman: Center for Pain and the Brain (P.A.I.N Group), Department of Anesthesiology, Critical Care & Pain Medicine, Boston Children’s Hospital, Boston, MA 02115, USA
John Giordano: South Beach Detox & Treatment Center, North Miami Beach, FL 33169, USA
Rehan Jalali: The Kenneth Blum Behavioral & Neurogenetic Institute, Austin, TX 78701, USA
Rajendra D. Badgaiyan: Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX 78229, USA
Edward J. Modestino: Department of Psychology, Curry College, Milton, MA 02186, USA
Mark S. Gold: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
Eric R. Braverman: The Kenneth Blum Behavioral & Neurogenetic Institute, Austin, TX 78701, USA
Anish Bajaj: Bajaj Chiropractic, New York, NY 10010, USA
Kenneth Blum: The Kenneth Blum Behavioral & Neurogenetic Institute, Austin, TX 78701, USA

IJERPH, 2022, vol. 19, issue 1, 1-12

Abstract: In the United States, amid the opioid overdose epidemic, nonaddicting/nonpharmacological proven strategies are available to treat pain and manage chronic pain effectively without opioids. Evidence supporting the long-term use of opioids for pain is lacking, as is the will to alter the drug-embracing culture in American chronic pain management. Some pain clinicians seem to prefer classical analgesic agents that promote unwanted tolerance to analgesics and subsequent biological induction of the “addictive brain”. Reward genes play a vital part in modulation of nociception and adaptations in the dopaminergic circuitry. They may affect various sensory and affective components of the chronic pain syndromes. The Genetic Addiction Risk Severity (GARS) test coupled with the H-Wave at entry in pain clinics could attenuate pain and help prevent addiction. The GARS test results identify high-risk for both drug and alcohol, and H-Wave can be initiated to treat pain instead of opioids. The utilization of H-Wave to aid in pain reduction and mitigation of hedonic addictive behaviors is recommended, notwithstanding required randomized control studies. This frontline approach would reduce the possibility of long-term neurobiological deficits and fatalities associated with potent opioid analgesics.

Keywords: Genetic Addiction Risk Severity (GARS); H-Wave; substance use disorder; Reward Deficiency Syndrome; RDS; hypodopaminism (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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