The Risk Factors for Development of Type 2 Diabetes: Panasonic Cohort Study 4

Yuto Saijo, Hiroshi Okada, Masahide Hamaguchi, Momoko Habu, Kazushiro Kurogi, Hiroaki Murata, Masato Ito and Michiaki Fukui
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Yuto Saijo: Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan
Hiroshi Okada: Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi 570-8540, Japan
Masahide Hamaguchi: Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan
Momoko Habu: Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi 570-8540, Japan
Kazushiro Kurogi: Department of Health Care Center, Panasonic Health Insurance Organization, Moriguchi 570-8540, Japan
Hiroaki Murata: Department of Orthopaedic Surgery, Matsushita Memorial Hospital, Moriguchi 570-8540, Japan
Masato Ito: Department of Health Care Center, Panasonic Health Insurance Organization, Moriguchi 570-8540, Japan
Michiaki Fukui: Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan

IJERPH, 2022, vol. 19, issue 1, 1-9

Abstract: (1) Background: As no study has evaluated the risk factors contributing to the development of type 2 diabetes according to body weight mass (BMI) categories in a large cohort and over a long period in a Japanese population, we aimed to assess them in 46,001 Japanese individuals; (2) Methods: This long-term retrospective cohort study included individuals who participated in a medical health checkup program at Panasonic Corporation from 2008 to 2018. In total, 3,208 participants developed type 2 diabetes. The BMI at 2008 were divided into 3 groups: BMI < 22 kg/m 2 , 22 ≤ BMI < 25 kg/m 2 , and BMI ≥ 25 kg/m 2 to evaluate the risk factors for type 2 diabetes; (3) Results: Cox regression analyses revealed that the significant risk factors were age, BMI, systolic blood pressure, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, fasting plasma glucose, current smoking status, and alcohol consumption in populations with BMI ≥ 25.0 kg/m 2 . The risk factors in the population with 22 ≤ BMI < 25 kg/m 2 were identical to that of BMI ≥ 25.0 kg/m 2 excluding systolic blood pressure, low-density lipoprotein cholesterol, and skipping breakfast. However, in the population with BMI < 22.0 kg/m 2 , no association was found as to BMI, SBP, LDL cholesterol level, and triglycerides; (4) Conclusions: The risk factors for developing diabetes were quite different between the population with BMI < 22 kg/m 2 and the population with 22 ≤ BMI < 25 kg/m 2 or BMI ≥ 25 kg/m 2 in a Japanese population.

Keywords: type 2 diabetes; body mass index; database research; cohort study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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