Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project

Beate I. Escher, Marja Lamoree, Jean-Philippe Antignac, Martin Scholze, Matthias Herzler, Timo Hamers, Tina Kold Jensen, Marc Audebert, Francois Busquet, Dieter Maier, Michael Oelgeschläger, Maria João Valente, Henriette Boye, Sebastian Schmeisser, Gaud Dervilly, Matteo Piumatti, Soléne Motteau, Maria König, Kostja Renko, Maria Margalef, Ronan Cariou, Yanying Ma, Andreas Frederik Treschow, Andreas Kortenkamp and Anne Marie Vinggaard ()
Additional contact information
Beate I. Escher: Department of Cell Toxicology, Helmholtz Centre for Environmental Research—UFZ, DE-04318 Leipzig, Germany
Marja Lamoree: Department Environment & Health, Faculty of Science, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Jean-Philippe Antignac: LABERCA, Oniris, INRAE, 44307 Nantes, France
Martin Scholze: Centre for Pollution Research and Policy, Environmental Sciences Division, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK
Matthias Herzler: German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany
Timo Hamers: Department Environment & Health, Faculty of Science, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Tina Kold Jensen: Department of Environmental Medicine, University of Southern Denmark, DK-5000 Odense, Denmark
Marc Audebert: Toxalim, UMR1331, INRAE, 31027 Toulouse, France
Francois Busquet: Altertox Academy, 1050 Brussels, Belgium
Dieter Maier: Biomax Informatics AG, 82152 Planegg, Germany
Michael Oelgeschläger: German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany
Maria João Valente: National Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
Henriette Boye: Odense Child Cohort, Hans Christian Andersen Hospital for Children, Odense University Hospital, DK-5000 Odense, Denmark
Sebastian Schmeisser: German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany
Gaud Dervilly: LABERCA, Oniris, INRAE, 44307 Nantes, France
Matteo Piumatti: Altertox Academy, 1050 Brussels, Belgium
Soléne Motteau: LABERCA, Oniris, INRAE, 44307 Nantes, France
Maria König: Department of Cell Toxicology, Helmholtz Centre for Environmental Research—UFZ, DE-04318 Leipzig, Germany
Kostja Renko: German Federal Institute for Risk Assessment (BfR), 10589 Berlin, Germany
Maria Margalef: Department Environment & Health, Faculty of Science, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
Ronan Cariou: LABERCA, Oniris, INRAE, 44307 Nantes, France
Yanying Ma: National Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
Andreas Frederik Treschow: National Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
Andreas Kortenkamp: Centre for Pollution Research and Policy, Environmental Sciences Division, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK
Anne Marie Vinggaard: National Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark

IJERPH, 2022, vol. 19, issue 20, 1-14

Abstract: Humans are involuntarily exposed to hundreds of chemicals that either contaminate our environment and food or are added intentionally to our daily products. These complex mixtures of chemicals may pose a risk to human health. One of the goals of the European Union’s Green Deal and zero-pollution ambition for a toxic-free environment is to tackle the existent gaps in chemical mixture risk assessment by providing scientific grounds that support the implementation of adequate regulatory measures within the EU. We suggest dealing with this challenge by: (1) characterising ‘real-life’ chemical mixtures and determining to what extent they are transferred from the environment to humans via food and water, and from the mother to the foetus; (2) establishing a high-throughput whole-mixture-based in vitro strategy for screening of real-life complex mixtures of organic chemicals extracted from humans using integrated chemical profiling (suspect screening) together with effect-directed analysis; (3) evaluating which human blood levels of chemical mixtures might be of concern for children’s development; and (4) developing a web-based, ready-to-use interface that integrates hazard and exposure data to enable component-based mixture risk estimation. These concepts form the basis of the Green Deal project PANORAMIX, whose ultimate goal is to progress mixture risk assessment of chemicals.

Keywords: mixture risk assessment; real-life mixtures; developmental neurotoxicity; reproductive toxicity; new methodological approaches; effect-directed analysis; effect-based trigger values; PANORAMIX (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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