Continuous Oral Administration of Sonicated P. gingivalis Delays Rat Skeletal Muscle Healing Post-Treadmill Training

Kairi Hayashi (), Yasuo Takeuchi, Shintaro Shimizu, Gen Tanabe, Hiroshi Churei, Hiroaki Kobayashi and Toshiaki Ueno
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Kairi Hayashi: Department of Masticatory Function and Health Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Yasuo Takeuchi: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Shintaro Shimizu: Department of Masticatory Function and Health Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Gen Tanabe: Department of Oral Microbiology, Asahi University School of Dentistry, Gifu 501-0296, Japan
Hiroshi Churei: Department of Masticatory Function and Health Science, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Hiroaki Kobayashi: Department of Periodontology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Toshiaki Ueno: Department of Sports Dentistry, Meikai University School of Dentistry, Saitama 350-0283, Japan

IJERPH, 2022, vol. 19, issue 20, 1-10

Abstract: Background: A delay in muscle repair interferes with the effect of training or exercise; therefore, it is important to identify the factors that delay muscle repair. P. gingivalis , one of the most common periodontal disease pathogens, has the potential to inhibit muscle repair after training, as inferred from a previous study. To assess the expression of satellite cells in this in vivo study, we evaluated the relationship between P. gingivalis and muscle regeneration after training. Methods: A total of 20 male Wistar rats (eight weeks in age) were randomly divided into two groups: one orally administered sonicated P. gingivalis four times per week for six weeks (PG group) and one given no treatment (NT group). After four weeks of training using a treadmill, the gastrocnemius was evaluated using histology of the cross-sectional area (CSA) of myotubes and immunohistochemistry of the expression of skeletal muscle satellite cells. In addition, an endurance test was performed a day before euthanization. Results: The CSA and expression of Pax7+/MyoD− and Pax7+/MyoD+ cells were not significantly different between the groups. However, the expression of Pax7−/MyoD+ cells and running time until exhaustion were significantly lower in the PG group. Conclusions: Infection with P. gingivalis likely interferes with muscle repair after training.

Keywords: P. gingivalis; skeletal muscle; training; satellite cell (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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