Development of an Artificial Intelligence Model for Analyzing the Relationship between Imaging Features and Glucocorticoid Sensitivity in Idiopathic Interstitial Pneumonia

Ling Jiang, Meijiao Li, Han Jiang, Liyuan Tao, Wei Yang, Huishu Yuan () and Bei He ()
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Ling Jiang: Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China
Meijiao Li: Department of Radiology, Peking University Third Hospital, Beijing 100191, China
Han Jiang: OpenBayes (Tianjin) IT Co., Ltd., Beijing 100027, China
Liyuan Tao: Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China
Wei Yang: Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China
Huishu Yuan: Department of Radiology, Peking University Third Hospital, Beijing 100191, China
Bei He: Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China

IJERPH, 2022, vol. 19, issue 20, 1-11

Abstract: High-resolution CT (HRCT) imaging features of idiopathic interstitial pneumonia (IIP) patients are related to glucocorticoid sensitivity. This study aimed to develop an artificial intelligence model to assess glucocorticoid efficacy according to the HRCT imaging features of IIP. The medical records and chest HRCT images of 150 patients with IIP were analyzed retrospectively. The U-net framework was used to create a model for recognizing different imaging features, including ground glass opacities, reticulations, honeycombing, and consolidations. Then, the area ratio of those imaging features was calculated automatically. Forty-five patients were treated with glucocorticoids, and according to the drug efficacy, they were divided into a glucocorticoid-sensitive group and a glucocorticoid-insensitive group. Models assessing the correlation between imaging features and glucocorticoid sensitivity were established using the k-nearest neighbor (KNN) algorithm. The total accuracy (ACC) and mean intersection over union (mIoU) of the U-net model were 0.9755 and 0.4296, respectively. Out of the 45 patients treated with glucocorticoids, 34 and 11 were placed in the glucocorticoid-sensitive and glucocorticoid-insensitive groups, respectively. The KNN-based model had an accuracy of 0.82. An artificial intelligence model was successfully developed for recognizing different imaging features of IIP and a preliminary model for assessing the correlation between imaging features and glucocorticoid sensitivity in IIP patients was established.

Keywords: artificial intelligence; idiopathic interstitial pneumonia; imaging features; glucocorticoid sensitivity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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