Arteriovenous Malformation Hemorrhage in Pregnancy: A Systematic Review and Meta-Analysis

Ruhana Che Yusof, Mohd Noor Norhayati () and Yacob Mohd Azman
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Ruhana Che Yusof: Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia
Mohd Noor Norhayati: Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia
Yacob Mohd Azman: Medical Development Division, Ministry of Health, Level 7, Block E1, Parcel E, Federal Government Administrative Centre, Putrajaya 62590, Malaysia

IJERPH, 2022, vol. 19, issue 20, 1-13

Abstract: Hemorrhage of arteriovenous malformation (AVM) is a rare condition during pregnancy. This study was proposed to pool the proportion of AVM hemorrhage per pregnancy. A systematic review and meta-analysis with three databases were performed to review the studies published until April 2022. The Newcastle Ottawa Scale was used for risk assessment of data quality. The meta-analysis was conducted by a generic inverse variance of double arcsine transformation with a random model using Stata software. Twelve studies were included in this review. The pooled proportion of AVM hemorrhage per pregnancy was 0.16 (95% CI: 0.08, 0.26). The subgroup analyses were carried out based on world regions and study designs, and the study duration with the highest proportion of each subgroup was Europe [0.35 (95% CI: 0.02, 0.79)], with retrospective review [0.18 (95% CI: 007, 0.32)] and 10 to 20 years of study duration [0.37 (95% CI: 0.06, 0.77)]. The AVM hemorrhage per pregnancy in this review was considered low. However, the conclusion must be carefully interpreted since this review had a small study limitation.

Keywords: arteriovenous malformation; pregnancy; pooled proportion; double arcsine transformation; rare disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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