Genetic Evolution Analysis and Host Characteristics of Hantavirus in Yunnan Province, China

Na Wang, Jia-Xiang Yin (), Yao Zhang, Li Wu, Wen-Hong Li, Yun-Yan Luo, Rui Li, Zi-Wei Li and Shu-Qing Liu
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Na Wang: School of Public Health, Dali University, Dali 671000, China
Jia-Xiang Yin: School of Public Health, Dali University, Dali 671000, China
Yao Zhang: School of Public Health, Dali University, Dali 671000, China
Li Wu: School of Public Health, Dali University, Dali 671000, China
Wen-Hong Li: School of Public Health, Dali University, Dali 671000, China
Yun-Yan Luo: School of Public Health, Dali University, Dali 671000, China
Rui Li: School of Public Health, Dali University, Dali 671000, China
Zi-Wei Li: School of Public Health, Dali University, Dali 671000, China
Shu-Qing Liu: School of Public Health, Dali University, Dali 671000, China

IJERPH, 2022, vol. 19, issue 20, 1-11

Abstract: For a long time, the epidemic situation of hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus (HV) in Yunnan Province of China has been relatively severe. The molecular epidemiology and host characteristics of HV in Yunnan Province are still not completely clear, and the systematic and long-term investigation of the epidemic area is very limited. In this study, a total of 488 murine-shaped animals were captured in the three regions of Mile City, Mangshi City and Lianghe County in Yunnan Province, and then the type of HV was identified by multiplex real-time RT-PCR and sequenced. The results indicate that 2.46% of the murine-shaped animal specimens were infected with HV. A new subtype of Seoul virus (SEOV) was found in the rare rat species Rattus nitidus in Lianghe County, and the two strains of this new subtype were named YNLH-K40 and YNLH-K53. Through the phylogenetic analysis of this new subtype, it is shown that this new subtype is very similar to the type S5 of SEOV, which is previously described as the main cause for the high incidence of HFRS in Longquan City, Zhejiang Province, China. This new subtype is highly likely to cause human infection and disease. Therefore, in addition to further promoting the improvement of the HV gene database and strengthening the discovery and monitoring of the host animals in Yunnan Province, more attention should be paid to the pathogenic potential of the newly discovered HV type.

Keywords: hantavirus; hemorrhagic fever with renal syndrome (HFRS); genetic diversity; host (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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