Increased Risk of Fractures and Use of Proton Pump Inhibitors in Menopausal Women: A Systematic Review and Meta-Analysis

Thuila Ferreira da Maia, Bruna Gafo de Camargo, Meire Ellen Pereira, Cláudia Sirlene de Oliveira and Izonete Cristina Guiloski ()
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Thuila Ferreira da Maia: Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil
Bruna Gafo de Camargo: Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil
Meire Ellen Pereira: Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil
Cláudia Sirlene de Oliveira: Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil
Izonete Cristina Guiloski: Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil

IJERPH, 2022, vol. 19, issue 20, 1-10

Abstract: Proton pump inhibitors (PPIs) can directly interfere with osteoclastic function, induce hypergastrinemia, and inhibit calcium absorption, leading to reduced bone mineral density (BMD), a measure of bone metabolism that may be associated with the risk of fractures. The current study involves a systematic review and meta-analysis aimed at assessing the relationship between prolonged use of PPI drugs and fractures in menopausal women. A systematic search and meta-analysis were performed on PubMed, Scopus, and Science Direct databases according to PRISMA guidelines. Two independent reviewers analyzed the articles. The five articles found in the databases, which met the eligibility criteria, covered participants who were menopausal women aged between 56 and 78.5 years, using or not using a PPI for a minimum of 12 months. All studies showed an increase in the rate of fractures related to using PPIs, as an outcome. Prolonged use of PPIs in menopausal women can affect bone metabolism and cause fractures. However, other factors, such as the use of other classes of drugs, obesity, low weight, poor diet, replacement hormones, and comorbidities, should also be considered for assessing the risk of fractures.

Keywords: fracture risk; menopause; proton pump inhibitors; woman (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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