Association between Statin Use and Diabetes Risk in Patients with Transient Ischemic Attack

Fu-Jun Chen, Ming-Chien Yin, Pei-Yun Chen, Min-Hua Lin, Yi-Hao Peng (), Wen-Chao Ho (), Pau-Chung Chen and Chung Y. Hsu
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Fu-Jun Chen: Department of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404327, Taiwan
Ming-Chien Yin: Division of Respiratory Therapy, China Medical University Hospital, Taichung 404327, Taiwan
Pei-Yun Chen: Department of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404327, Taiwan
Min-Hua Lin: Department of Dietetics, Yunlin Christian Hospital, Yunlin 64866, Taiwan
Yi-Hao Peng: Department of Respiratory Therapy, Asia University Hospital, Asia University, Taichung 41354, Taiwan
Wen-Chao Ho: Department of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404327, Taiwan
Pau-Chung Chen: Department of Public Health, National Taiwan University, Taipei 10617, Taiwan
Chung Y. Hsu: Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404327, Taiwan

IJERPH, 2022, vol. 19, issue 21, 1-9

Abstract: Statin therapy can effectively reduce recurrent transient ischemic attack (TIA) risk. However, studies have reported that statin use is associated with incidence of diabetes mellitus (DM). Whether statin therapy remains associated with higher DM risk in patients with TIA remains unknown. This study investigated whether statin treatment influences incident DM risk in patients with TIA. We conducted a retrospective cohort study using the Longitudinal Health Insurance Database 2000. Participants who were newly diagnosed with TIA (ICD-9-CM code 435) from 1 January 1997 to 31 December 2011 were recruited. The Kaplan–Meier method and Cox proportional risk model of time-dependent covariance were used. We enrolled 8342 patients with newly diagnosed TIA from 1 January 1997 to 31 December 2011. Of these, 1255 patients were classified as statin users and 7087 as nonusers. During the 14-year follow-up, the incidence of newly diagnosed DM was 0.545-fold lower in the statins group compared with nonusers (95% confidence interval [CI] = 0.457–0.650). According to cumulative defined daily doses (cDDDs), the adjusted hazard ratios for DM were 0.689, 0.594, and 0.463 when patients were treated with statins at cDDDs = 28–89, 90–180, and >180, respectively. In patients with TIA, statin use is associated with a lower incident DM risk compared with the nonuse of statins.

Keywords: cohort study; diabetes mellitus; transient ischemic attack; statins (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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