Oxidative Stress Responses and Gene Transcription of Mice under Chronic-Exposure to 2,6-Dichlorobenzoquinone

Wenjing Wu, Yingying Liu, Chunze Li, Fangyu Zhuo, Zexiong Xu, Huachang Hong, Hongjie Sun (), Xianfeng Huang and Xinwei Yu ()
Additional contact information
Wenjing Wu: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Yingying Liu: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Chunze Li: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Fangyu Zhuo: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Zexiong Xu: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Huachang Hong: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Hongjie Sun: College of Geography and Environmental Science, Zhejiang Normal University, Jinhua 321004, China
Xianfeng Huang: National and Local Joint Engineering Research Center for Ecological Treatment Technology of Urban Water Pollution, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
Xinwei Yu: Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, Zhoushan Municipal Center for Disease Control and Prevention, Zhoushan 316021, China

IJERPH, 2022, vol. 19, issue 21, 1-9

Abstract: 2,6-Dichlorobenzoquinone (2,6-DCBQ), as an emerging disinfection by-production, was frequently detected and identified in the drinking water; however, limited information is available for the toxic effect of 2,6-DCBQ on mice. In the present study, adult mice were used to assess the impact of 2,6-DCBQ via measuring the responses of antioxidant enzymes (superoxide dismutase (SOD) and catalase (CAT)), the key genes (Heme oxygenase-1 (HO-1), NADPH quinone oxidoreductase 1 (NQO1) and glutamate-L-cysteine ligase catalytic subunit (GCLC)) in the Nrf2-keap1 pathway, and lipid peroxidation (malonaldehyde, MDA). Our results clearly indicated that 2,6-DCBQ decreased the activities of SOD and CAT, repressed the transcriptional levels of key genes in Nrf2-keap1 pathway, further caused oxidative damage on mice. These results provided evidence for assessing the threat of 2,6-DCBQ on human.

Keywords: 2,6-dichlorobenzoquinone; mouse; oxidative stress; lipid peroxidation; Nrf2-keap1; mRNA transcription (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/21/13801/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/21/13801/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:21:p:13801-:d:951332

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().