Toxic Encephalopathy and Methemoglobinemia after 5-Amino-2-(trifluoromethyl)pyridine Poisoning

Yiming Tao, Longke Shi, Jie Han, Xiangdong Jian () and Yongsheng Li ()
Additional contact information
Yiming Tao: Department of Intensive Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China
Longke Shi: School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Jie Han: Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China
Xiangdong Jian: Department of Poisoning and Occupational Diseases, Qilu Hospital of Shandong University, No. 107, Road Wenhuaxi, Jinan 250012, China
Yongsheng Li: Department of Intensive Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China

IJERPH, 2022, vol. 19, issue 21, 1-6

Abstract: The aromatic amino compound 5-amino-2-(trifluoromethyl)pyridine acts as an intermediate in the synthesis of pharmaceutical products. However, the toxicity profile of this compound is sparse and no related poisoning events have been reported. Here, we report the case of a 35-year-old man who inhaled 5-amino-2-(trifluoromethyl)pyridine at work. After inhalation, the patient rapidly developed symptoms such as dizziness, fatigue, nausea, vomiting, chest tightness, and loss of consciousness. After admission, methemoglobinemia, hemolytic anemia, acute renal failure, and toxic encephalopathy occurred. Symptoms improved significantly after intravenous treatment with a low dose of methylene blue. This revealed that 5-amino-2-(trifluoromethyl)pyridine is toxic to the human body and can be absorbed through the respiratory tract, resulting in methemoglobinemia and toxic encephalopathy; thus, caution should be taken in industrial production.

Keywords: 5-amino-2-(trifluoromethyl)pyridine; methemoglobinemia; acute renal failure; toxic encephalopathy; magnetic resonance imaging (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/21/14031/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/21/14031/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:21:p:14031-:d:955781

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().