Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

Haniyeh Moaven, Annesi Giacaman, Víctor Beltrán (), Ye Han Sam, Daniel Betancur, Giuseppe Mainas, Seyed Ali Tarjomani, Nikolaos Donos and Vanessa Sousa ()
Additional contact information
Haniyeh Moaven: Centre for Oral Clinical Research, Centre for Oral Immunobiology & Regenerative Medicine, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London E1 2AD, UK
Annesi Giacaman: Center of Excellence in Translational Medicine, Faculty of Medicine, Universidad de la Frontera, Temuco 4780000, Chile
Víctor Beltrán: Clinical Investigation and Dental Innovation Center, Dental School & Center for Translational Medicine, Universidad de La Frontera, Temuco 4780000, Chile
Ye Han Sam: Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK
Daniel Betancur: Discipline of Periodontology, Department of Surgical Stomatology, Faculty of Dentistry, Universidad de Concepción, Concepción 4030000, Chile
Giuseppe Mainas: Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK
Seyed Ali Tarjomani: Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK
Nikolaos Donos: Centre for Oral Clinical Research, Centre for Oral Immunobiology & Regenerative Medicine, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London E1 2AD, UK
Vanessa Sousa: Periodontology and Periodontal Medicine, Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT, UK

IJERPH, 2022, vol. 19, issue 21, 1-24

Abstract: The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1β and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-α reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain ™ (EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.

Keywords: biomarkers; peri-implantitis; inflammation; therapy; laser; amelogenin (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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