Does REM Sleep-Dependent Obstructive Sleep Apnea Have Clinical Significance?

Seung Cheol Lee, Doh-Eui Kim, Young Hwangbo, Mei Ling Song, Kwang Ik Yang () and Yong Won Cho ()
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Seung Cheol Lee: Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Korea
Doh-Eui Kim: Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Korea
Young Hwangbo: Department of Preventive Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Korea
Mei Ling Song: Department of Nursing Science, College of Nursing, Daegu Health College, 15, Yeongsong-ro, Buk-gu, Daegu 41453, Korea
Kwang Ik Yang: Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongnam-gu, Cheonan-si 31151, Korea
Yong Won Cho: Department of Neurology, School of Medicine, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea

IJERPH, 2022, vol. 19, issue 21, 1-9

Abstract: (1) Background: The clinical significance of rapid eye movement (REM) sleep-dependent obstructive sleep apnea (OSA) remains controversial because various criteria have been used to describe it. This study determined the clinical significance of REM-OSA in Koreans using data from patients with sufficient total sleep time (TST) and REM sleep duration. (2) Methods: We investigated 1824 patients with OSA who were diagnosed by polysomnography (PSG). REM-OSA was defined as an overall apnea–hypopnea index (AHI) ? 5, NREM-AHI < 15, and REM-AHI/NREM-AHI ? 2. Demographic and medical data were collected from digital medical records and sleep questionnaires. We compared clinical and PSG data between REM-OSA and REM sleep-nondependent OSA (nREM-OSA). (3) Results: In total, 140 patients (20.2%) were categorized as REM-OSA. Those patients were predominantly female (53.6% vs. 21.7% of the overall cohort, p < 0.001). REM-OSA is frequent in the mild (69.3% vs. 18.8%) to moderate (30% vs. 27.9%) range of OSA ( p < 0.001). (4) Conclusions: The prevalence of REM-OSA was similar to that in previous study findings: frequent in mild to moderate OSA and females, which is consistent with results in Western populations. Our findings suggest that REM-OSA does not have clinical significance as a subtype of OSA.

Keywords: REM sleep; obstructive sleep apnea; polysomnography; Korea (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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