The Prevalence of Anticitrullinated Protein Antibodies in Older Poles—Results from a Population-Based PolSenior Study

Anna Chudek (), Przemysław Kotyla, Małgorzata Mossakowska, Tomasz Grodzicki, Tomasz Zdrojewski, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek and Aleksander J. Owczarek
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Anna Chudek: Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland
Przemysław Kotyla: Department of Internal Medicine, Rheumatology and Clinical Immunology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-635 Katowice, Poland
Małgorzata Mossakowska: Study on Ageing and Longevity, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland
Tomasz Grodzicki: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 31-531 Krakow, Poland
Tomasz Zdrojewski: Division of Preventive Medicine and Education, Medical University of Gdansk, 80-211 Gdansk, Poland
Magdalena Olszanecka-Glinianowicz: Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland
Jerzy Chudek: Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, 40-029 Katowice, Poland
Aleksander J. Owczarek: Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland

IJERPH, 2022, vol. 19, issue 21, 1-12

Abstract: Little is known about the occurrence of antibodies in older subjects. We analyzed the prevalence of anticitrullinated protein antibodies (anti-CCP) in a representative cohort of Polish older adults, participants of PolSenior substudy. Randomly selected 1537 serum samples of community-dwelling participants aged 65 and over. Questionnaires were completed by qualified interviewers and laboratory assessments served as a database for this analysis. The frequency of anti-CCP seropositivity (N = 50) was estimated at 3.25% (95% CI: 2.45–4.30%), being higher among women—4.05% (2.83–5.73%) than men—2.41% (1.48–3.86%). The frequency of anti-CCP seropositivity was decreasing with age from 4.29% in aged 65–74 years and 4.07% in 70–84 years to 1.50% in aged 85 years or above ( p < 0.05). Hypoalbuminemia, inflammatory status (C-reactive protein >10 mg/dL or interleukin-6 ≥10 pg/mL), and female gender were associated with increased, while age ≥85 years with decreased risk of seropositivity. Multivariable logistic regression revealed that hypoalbuminemia, inflammatory status, and age ≥85 years were independently associated factors of anti-CCP seropositivity. The decreased frequency of anti-CCP seropositivity in the oldest old suggests shorter survival of the seropositive individuals who developed rheumatoid arthritis. It seems that low symptomatic RA remains frequently undiagnosed in older subjects.

Keywords: older adults; anti-CPP prevalence; rheumatoid arthritis; ACPA; anticitrullinated protein antibodies (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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