Hyaluronic Acid: A New Approach for the Treatment of Gingival Recession—A Systematic Review

Vini Mehta (), Gerta Kaçani, Mohammed M. Al Moaleem (), Anwar Abdulkarim Almohammadi, Malak Mohammed Alwafi, Abduljabbar Khalil Mulla, Shahad Owaidh Alharbi, Abdullah Waleed Aljayyar, Etleva Qeli, Çeljana Toti, Agron Meto and Luca Fiorillo
Additional contact information
Vini Mehta: Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune 411018, India
Gerta Kaçani: Department of Prosthetic, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania
Mohammed M. Al Moaleem: Department of Prosthetic Dental Science, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia
Anwar Abdulkarim Almohammadi: College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia
Malak Mohammed Alwafi: College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia
Abduljabbar Khalil Mulla: College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia
Shahad Owaidh Alharbi: College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia
Abdullah Waleed Aljayyar: College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia
Etleva Qeli: Department of Conservative, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania
Çeljana Toti: Department of Prosthetic, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania
Agron Meto: Department of Dentistry, University of Aldent, 1007 Tirana, Albania
Luca Fiorillo: Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98100 Messina, Italy

IJERPH, 2022, vol. 19, issue 21, 1-11

Abstract: This systematic review aimed to investigate the effectiveness of hyaluronic acid (HA) on the clinical treatment outcomes of patients with gingival recession. A systematic search was performed in PubMed, Cochrane Central Register of Controlled Trials, Embase, Scopus, and Google Scholar for studies up to 15 August 2022. Two reviewers separately selected the papers for eligibility after conducting a thorough search. The study includes randomized controlled clinical trials in which participants were given HA in addition to periodontal treatment surgical procedures. The changes following the treatment protocol were evaluated for complete and mean root coverage as a primary outcome and gingival recession gain as the secondary outcome. Three articles met the eligibility criteria out of 557 titles. In periodontal surgery, HA exhibited better results in complete root coverage and mean root coverage when compared to the control group. Gingival recession reduction, clinical attachment level, and keratinized tissue gain were significantly increased compared to the control groups. However, the comparison presented in the following study might show heterogeneity among the studies and risk of bias in general. Given the scope of this analysis, results suggest that adjunctive treatment with HA gel for root coverage could be clinically beneficial.

Keywords: gingival recession; Miller class I and II; hyaluronic acid; root coverage (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/21/14330/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/21/14330/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:21:p:14330-:d:960979

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().