The Correlation between Two Angiotensin-Converting Enzyme Inhibitor’s Concentrations and Cognition

Attila Nagy, Réka Májer, Enikő Csikai, Adrienn Dobos, Gábor Süvegh and László Csiba ()
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Attila Nagy: Department of Health Informatics, Faculty of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary
Réka Májer: Department of Neurology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Enikő Csikai: Doctoral School of Health Sciences, Institute of Behavioral Science, Faculty of General Medicine, University of Debrecen, 4032 Debrecen, Hungary
Adrienn Dobos: Department of Forensic Toxicology, Hungarian Institute for Forensic Sciences, 1903 Budapest, Hungary
Gábor Süvegh: Department of Forensic Toxicology, Hungarian Institute for Forensic Sciences, 1903 Budapest, Hungary
László Csiba: Department of Neurology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary

IJERPH, 2022, vol. 19, issue 21, 1-8

Abstract: Both lisinopril and enalapril are angiotensin-converting enzyme (ACE) drugs and widely used in the treatment of hypertension. Enalapril does not cross the blood–brain barrier, but lisinopril is centrally active. Our goal was to find out if there was a link between the actual concentration of ACE inhibitors and cognition and if there was a detectable difference between the two types of ACE inhibitors. Asymptomatic, non-treated patients were diagnosed by screening and the hypertension was confirmed by ambulatory blood pressure monitoring (ABPM). A battery of cognitive tests was used to assess the impact of randomly assigning participants to receive either lisinopril or enalapril. All neurocognitive functions were measured, especially the most affected by conditions of compromised perfusion pressures, such as hypertension, which are attention and executive functions. The lisinopril concentration showed a significant inverse correlation with mosaic test (coeff. = −0.5779) and seemed to have a significant negative effect on perceptual motor skills (coeff. = −0.5779), complex attention (coeff. = −0.5104) and learning (coeff. = −0.5202). Compared with enalapril, lisinopril is less successful in improving the components of cognitive functions.

Keywords: ACE inhibitors; lisinopril; enalapril; cognitive tests (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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