Expression of Matrix Metalloproteinase-2,-7,-9 in Serum during Pregnancy in Patients with Pre-Eclampsia: A Prospective Study

Ayibaota Bahabayi, Nan Yang, Tong Xu, Yuting Xue, Lijuan Ma, Xunke Gu, Yongqing Wang and Keke Jia ()
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Ayibaota Bahabayi: Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China
Nan Yang: Department of Blood Transfusion, Peking University Third Hospital, Beijing 100191, China
Tong Xu: Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China
Yuting Xue: Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China
Lijuan Ma: Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China
Xunke Gu: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
Yongqing Wang: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
Keke Jia: Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China

IJERPH, 2022, vol. 19, issue 21, 1-11

Abstract: Background: Matrix Metalloproteinases (MMPs) have been found to have important roles in vascular pathology and may be involved in the occurrence of pre-eclampsia. In this study, the serum levels of MMP-2, -7, -9 in normal pregnant women and pre-eclampsia patients were analyzed to assess their predictive value. Methods: A total of 1563 pregnant women from Peking University Third Hospital, from February 2021 to October 2021, were enrolled. Serum samples were collected from patients one to three times, during the different trimesters. Among the 102 singleton pre-eclampsia patients, we collected samples from 33 patients in the first trimester (6–13 GW), 33 in the second trimester (14–28 GW), 41 in the third trimester (29–41 GW) and 28 after onset of pre-eclampsia. Samples from each trimester were collected before the onset of pre-eclampsia. Then we selected 35, 37, 43 and 25 samples from 124 healthy pregnant women by matching their age, BMI and gestational weeks, using these as the control groups. Serum levels of MMP-2, -7, -9 were detected by ELISA. The receiver operating characteristic (ROC) curve was used to evaluate their predictive value. Results: Except for the first trimester, MMP-2 and MMP-7 were significantly higher in the pre-eclampsia group ( p < 0.5). Additionally, in the pre-eclampsia group, MMP-9 increased significantly in the first trimester and after the onset of pre-eclampsia but decreased significantly in the second and third trimesters ( p < 0.5). The ROC curve indicated that MMP-9, MMP-2 and MMP-7 were the best indicators for predicting pre-eclampsia in the first, second and third trimesters, respectively. Conclusion: Increased MMP-2 and MMP-7 levels and a decreased MMP-9 level seem to be related to the pathogenesis of pre-eclampsia and are expected to be potential predictors of pre-eclampsia.

Keywords: pre-eclampsia; matrix metalloproteinase-2; matrix metalloproteinase-7; matrix metalloproteinase-9; normal pregnancy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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