Immune Status of Workers with Professional Risk of Being Affected by Chrysotile Asbestos in Kazakhstan

Sholpan Koigeldinova, Alexey Alexeyev (), Zhengisbek Zharylkassyn, Yertay Otarov, Bauyrzhan Omarkulov, Magzhan Tilemissov and Chingiz Ismailov
Additional contact information
Sholpan Koigeldinova: Department of Internal Diseases, Karaganda Medical University, 40 Gogol street, Karaganda 100008, Kazakhstan
Alexey Alexeyev: Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan
Zhengisbek Zharylkassyn: Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan
Yertay Otarov: Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan
Bauyrzhan Omarkulov: Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan
Magzhan Tilemissov: Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan
Chingiz Ismailov: Institute of Public Health and Professional Health, Karaganda Medical University, 15 Mustafin street, Karaganda 100008, Kazakhstan

IJERPH, 2022, vol. 19, issue 21, 1-8

Abstract: The purpose of this research was to study the particularities of the immune status of workers in the field of chrysotile asbestos production, depending on their work experience and professional risk of being affected by chrysotile dust. The research covered 125 men, who were workers at the only enterprise dealing with the extraction and beneficiation of chrysotile ores in Kazakhstan. Indicants of cell immunity were detected by flow cytometry; IgA, IgM, and IgG were detected by a multiplex immunological assay. It was found that, among workers impacted by chrysotile asbestos for more than 15 years, compared with individuals who were not impacted by asbestos dust, the level of CD3+ T-cells was decreased ( t = −8.76, p < 0.001), as well as the number of CD4+ T-cells (U = 1246.0, p < 0.001). Moreover, CD8+ T-cells increased ( t = 5.308, p = 0.001), and neutrophil phagocytic activity also increased, by 1.2 times (U = 305.5, p < 0.001). It was found that working under the condition of professional contact with chrysotile asbestos dust modifies the indicants of humoral immunity, IgA, IgM, and IgG, to a lesser extent than those of cellular immunity.

Keywords: cellular immunity; humoral immunity; chrysotile asbestos; work experience; professional risk; occupational diseases (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/21/14603/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/21/14603/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:21:p:14603-:d:965465

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().