Evaluation of the Effect of Cariprazine on Memory and Cognition in Experimental Rodent Models

Hristina Ivanova Zlatanova (), Maria Todorova Georgieva-Kotetarova, Natalia Borisova Vilmosh and Ilin Kostadinov Kandilarov
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Hristina Ivanova Zlatanova: Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria
Maria Todorova Georgieva-Kotetarova: Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria
Natalia Borisova Vilmosh: Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria
Ilin Kostadinov Kandilarov: Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Medical University Plovdiv, 4002 Plovdiv, Bulgaria

IJERPH, 2022, vol. 19, issue 22, 1-11

Abstract: The main symptoms of schizophrenia are categorized as positive, negative, and cognitive. Cognitive impairments do not generally respond to antipsychotics. Cariprazine is a novel antipsychotic conceived with the idea that high affinity for D3 receptors may elicit a favorable response in the management of cognitive deficits. We evaluated the pro-cognitive properties of 14-day long pre-treatment with cariprazine (0.25, 0.5, and 1 mg/kg b.w. intraperitoneally) in experimental rodent models with scopolamine-induced memory impairment employing novel object recognition test (NORT), T-maze, Y-maze, and passive avoidance tasks (step-through and step-down). Statistical analysis was performed with One Way ANOVA. In NORT cariprazine increased the recognition index. In T-maze and Y-maze cariprazine increased the working memory index as well as the percentage of spontaneous alternation. Cariprazine improved learning and memory in both short-term and long-term memory retention tests in step-down and step-through tasks. Cariprazine improves learning, recognition, and spatial memory in rats with scopolamine-induced memory impairment. Cariprazine’s beneficial effect on cognition is likely due to its affinity for D3 receptors, as well as agonism at 5-HT1A receptors. Most probably, the cognitive-enhancing properties of cariprazine are the result of integrated modulation in the amygdala, hippocampus, and prefrontal cortex.

Keywords: cariprazine; scopolamine; recognition; maze learning; spatial memory; avoidance learning (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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