Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?

Fadi G. Mirza, Muna A. Tahlak, Rachelle Bou Rjeili, Komal Hazari, Farah Ennab, Charlie Hodgman, Amar Hassan Khamis and William Atiomo ()
Additional contact information
Fadi G. Mirza: Latifa Women and Children Hospital, Dubai P.O. Box 9115, United Arab Emirates
Muna A. Tahlak: Latifa Women and Children Hospital, Dubai P.O. Box 9115, United Arab Emirates
Rachelle Bou Rjeili: Faculty of Medicine, American University of Beirut, Beruit P.O. Box 11-0236, Lebanon
Komal Hazari: Latifa Women and Children Hospital, Dubai P.O. Box 9115, United Arab Emirates
Farah Ennab: Department of Obstetrics and Gynaecology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Building 14, Dubai Healthcare City, Dubai P.O. Box 505055, United Arab Emirates
Charlie Hodgman: School of Biosciences, University of Nottingham, Loughborough LE12 5RD, UK
Amar Hassan Khamis: Department of Obstetrics and Gynaecology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Building 14, Dubai Healthcare City, Dubai P.O. Box 505055, United Arab Emirates
William Atiomo: Department of Obstetrics and Gynaecology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Building 14, Dubai Healthcare City, Dubai P.O. Box 505055, United Arab Emirates

IJERPH, 2022, vol. 19, issue 22, 1-15

Abstract: Polycystic ovary syndrome (PCOS) is a prevalent condition that not only has the potential to impede conception but also represents the most common endocrine dysfunction in fertile women. It is considered a heterogeneous and multifaceted disorder, with multiple reproductive and metabolic phenotypes which differently affect the early- and long-term syndrome’s risks. Undoubtedly, the impact of PCOS on infertility has attracted most of the attention of healthcare providers and investigators. However, there is growing evidence that even after conception is achieved, PCOS predisposes the parturient to several adverse pregnancy outcomes including a high risk of pregnancy-induced hypertension, spontaneous abortion, gestational diabetes, preeclampsia, and preterm birth, which increase the risks of stillbirth and neonatal death. Fetal growth abnormalities may also be more common, but the relationship is less well defined. This narrative review aims to summarize current knowledge regarding these conditions as they interplay with PCOS and concludes that although there appears to be an increase in these complications during the pregnancy of women with PCOS, there is a need for further research to clarify the possible confounding impact of obesity. Implications for clinical practice and future research are outlined.

Keywords: polycystic ovary syndrome; PCOS; pregnancy; obstetric; complications; obesity; miscarriage; diabetes; preterm; hypertension (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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