Impact of Physical Activity on the Characteristics and Metabolic Consequences of Alcohol Consumption: A Cross-Sectional Population-Based Study

Onni Niemelä (), Aini Bloigu, Risto Bloigu, Anni S. Halkola, Markus Niemelä, Mauri Aalto and Tiina Laatikainen
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Onni Niemelä: Department of Laboratory Medicine, Medical Research Unit, Seinäjoki Central Hospital and Tampere University, 60220 Seinäjoki, Finland
Aini Bloigu: Center for Life Course Health Research, University of Oulu, 90570 Oulu, Finland
Risto Bloigu: Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, 90570 Oulu, Finland
Anni S. Halkola: Department of Laboratory Medicine, Medical Research Unit, Seinäjoki Central Hospital and Tampere University, 60220 Seinäjoki, Finland
Markus Niemelä: Department of Laboratory Medicine, Medical Research Unit, Seinäjoki Central Hospital and Tampere University, 60220 Seinäjoki, Finland
Mauri Aalto: Department of Psychiatry, Seinäjoki Central Hospital and Tampere University, 33100 Tampere, Finland
Tiina Laatikainen: Department of Public Health and Social Welfare, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland

IJERPH, 2022, vol. 19, issue 22, 1-12

Abstract: Sedentary lifestyle and excessive alcohol drinking are major modifiable risk factors of health. In order to shed further light on the relationships between physical activity and health consequences of alcohol intake, we measured biomarkers of liver function, inflammation, lipid status and fatty liver index tests in a large population-based sample of individuals with different levels of physical activity, alcohol drinking and other lifestyle risk factors. The study included 21,050 adult participants (9940 men, 11,110 women) (mean age 48.2 ± 13.3 years) of the National FINRISK Study. Data on physical activity, alcohol drinking, smoking and body weight were recorded. The participants were classified to subgroups according to gender, levels of physical activity (sedentary, low, moderate, vigorous, extreme), alcohol drinking levels (abstainers, moderate drinkers, heavy drinkers) and patterns (regular or binge, types of beverages preferred in consumption). Serum liver enzymes (GGT, ALT), C-reactive protein (CRP) and lipid profiles were measured using standard laboratory techniques. Physical activity was linearly and inversely related with the amount of alcohol consumption, with the lowest alcohol drinking levels being observed in those with vigorous or extreme activity ( p < 0.0005). Physically active individuals were less frequently binge-type drinkers, cigarette smokers or heavy coffee drinkers than those with sedentary activity ( p < 0.0005 for linear trend in all comparisons). In the General Linear Model to assess the main and interaction effects of physical activity and alcohol consumption on biomarker status, as adjusted for anthropometric measures, smoking and coffee consumption, increasing levels of physical activity were found to be associated with more favorable findings on serum GGT ( p < 0.0005), ALT ( p < 0.0005 for men), cholesterol ( p = 0.025 for men; p < 0.0005 for women), HDL-cholesterol ( p < 0.0005 for men, p = 0.001 for women), LDL-cholesterol ( p < 0.03 for men), triglycerides ( p < 0.0005 for men, p < 0.03 for women), CRP ( p < 0.0005 for men, p = 0.006 for women) and fatty liver index ( p < 0.0005). The data support the view that regular moderate to vigorous physical activity may counteract adverse metabolic consequences of alcohol consumption on liver function, inflammation and lipid status. The role of physical activity should be further emphasized in interventions aimed at reducing health problems related to unfavorable risk factors of lifestyle.

Keywords: ethanol; lifestyle; obesity; physical exercise; smoking (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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