Birth Weight < 3rd Percentile Prediction Using Additional Biochemical Markers—The Uric Acid Level and Angiogenesis Markers (sFlt-1, PlGF)—An Exploratory Study

Magdalena Bednarek-Jędrzejek (), Sylwia Dzidek, Piotr Tousty, Ewa Kwiatkowska, Aneta Cymbaluk-Płoska, Tomasz Góra, Bartosz Czuba, Andrzej Torbé and Sebastian Kwiatkowski
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Magdalena Bednarek-Jędrzejek: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland
Sylwia Dzidek: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland
Piotr Tousty: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland
Ewa Kwiatkowska: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland
Aneta Cymbaluk-Płoska: Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, 70-204 Szczecin, Poland
Tomasz Góra: Clinical Department of Gynecology and Obstetrics, John Paul 2nd Municipal Hospital, 35-241 Rzeszow, Poland
Bartosz Czuba: Department of Obstetrics and Gynecology, Medical University of Silesia, 40-055 Ruda Slaska, Poland
Andrzej Torbé: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland
Sebastian Kwiatkowski: Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland

IJERPH, 2022, vol. 19, issue 22, 1-11

Abstract: (1) Aim: Ultrasound is the gold standard for assessing fetal growth disorders. The relationship between high sFlt-1/PlGF scores and LBW (low birth weight) was described. In this study, we attempted to assess whether uric acid could be used as a secondary marker in estimating the pregnancy risk associated with LBW. (2) Material and methods: 665 pregnant women with a suspected or confirmed form of placental insufficiency were enrolled. In each of the patients, sFlt-1 and PlGF and uric acid levels were determined. Patients were divided into two groups according to birth weight below and above the third percentile for the given gestational age with the criteria of the neonatal definition of FGR (fetal growth restriction). (3) Results: A significant negative correlation between neonatal birth weight and the uric acid level across the entire study group was observed. We found a significant negative correlation between neonatal birth weight and the uric acid level with birth weights < 3rd percentile. (4) Conclusions: There is a significant link between the uric acid concentration and LBW in the group with placental insufficiency. Uric acid can improve the prediction of LBW. An algorithm for LBW prognosis that makes use of biophysical (ultrasound) and biochemical (uric acid level, angiogenesis markers) parameters yields better results than using these parameters separately from each other.

Keywords: birth; weight (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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