Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players

Stefania Orrù, Esther Imperlini, Daniela Vitucci, Marianna Caterino, Annalisa Mandola, Morten Bredsgaard Randers, Jakob Friis Schmidt, Marie Hagman, Thomas Rostgaard Andersen, Peter Krustrup, Margherita Ruoppolo, Pasqualina Buono () and Annamaria Mancini
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Stefania Orrù: Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
Esther Imperlini: Department for Innovation in Biological, Agro-Food and Forest Systems, University of Tuscia, 01100 Viterbo, Italy
Daniela Vitucci: Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
Marianna Caterino: CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy
Annalisa Mandola: Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
Morten Bredsgaard Randers: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark
Jakob Friis Schmidt: Section for Anaesthesia for ENT, Head Neck & Maxillofacial Surgery and Ortopedi, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
Marie Hagman: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark
Thomas Rostgaard Andersen: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark
Peter Krustrup: Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense, Denmark
Margherita Ruoppolo: CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy
Pasqualina Buono: Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy
Annamaria Mancini: Department of Movement Sciences and Wellness, University Parthenope, 80133 Naples, Italy

IJERPH, 2022, vol. 19, issue 23, 1-19

Abstract: Background: Aging and sedentary behavior are independent risk factors for non-communicable diseases. An active lifestyle and structured physical activity are positively associated with a healthier quality of life in the elderly. Here, we explored the proteomic/metabolomic muscular signature induced by lifelong football training associated with successful aging. Methods: The study was performed on nine lifelong football players (67.3 ± 2.8 yrs) and nine aged-matched untrained subjects. We performed a proteomic/metabolomic approach on V. lateralis muscle biopsies; the obtained data were analyzed by means of different bioinformatic tools. Results: Our results indicated that lifelong football training is able to enhance the muscles’ oxidative capacity in the elderly by promoting fatty acids as preferential energetic substrates and hence determining a healthier body composition and metabolic profile; furthermore, we showed that the total polyamine content is higher in lifelong football players’ muscle, enforcing the involvement of polyamines in muscle growth and hypertrophy. Conclusions: Lifelong football training, as a structured physical activity, significantly influences the expression of the proteins and metabolites involved in oxidative metabolism and muscle hypertrophy associated with successful aging.

Keywords: lifelong football training; successful aging; mitochondrial oxidative capacity; polyamines (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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