Baseline Proteinuria and Serum Creatinine Concentration as Clinical Predictors of Complete Renal Response in Patients with Lupus Nephritis: A Single-Center Experience

Andrzej Konieczny (), Izabela Kasenberg, Aleksandra Mikołajczak, Piotr Donizy, Agnieszka Hałoń and Magdalena Krajewska
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Andrzej Konieczny: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
Izabela Kasenberg: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
Aleksandra Mikołajczak: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
Piotr Donizy: Division of Clinical Pathology, Department of Clinical and Experimental Pathology, Wroclaw Medical University, 50-556 Wroclaw, Poland
Agnieszka Hałoń: Division of Clinical Pathology, Department of Clinical and Experimental Pathology, Wroclaw Medical University, 50-556 Wroclaw, Poland
Magdalena Krajewska: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland

IJERPH, 2022, vol. 19, issue 23, 1-9

Abstract: The aim of the study was to identify robust predictors of complete renal response (CRR), within 36 months, in a single-center cohort of lupus nephritis (LN) patients. Patients with biopsy-confirmed LN who underwent kidney biopsy between 1 January 2010 and 31 December 2020 were included and followed up for at least 6 months. CRR was defined as a reduction of urinary protein-to-creatinine ratio (UPCR) below 0.50 g/g. We evaluated baseline demographic, laboratory, and biopsy characteristics as potential predictors of CRR, and selected the variables further evaluated with Kaplan–Meier curves and log-rank tests. The traits with a p -value < 0.1 were later tested with both uni- and multivariable Cox proportional hazard models. Our sample consisted of 57 patients (84% females, median age 32 years), out of which 63.2% reached CRR within 36 months. The initial UPCR and estimated glomerular filtration rate (eGFR) were the only variables in multivariable Cox regression model, which were selected through backward elimination, with a significance threshold <0.05 (HR = 0.77, p = 0.01 and HR = 1.02, p = 0.001). Our results confirmed the role of initial UPCR and serum creatinine concentration (sCr) as predictors of CRR in LN.

Keywords: systemic lupus erythematosus; lupus nephritis; proteinuria (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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