GRP78 Activity Moderation as a Therapeutic Treatment against Obesity

Dongjin Pan (), Yunzhu Yang, Aihua Nong, Zhenzhou Tang () and Qing X. Li
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Dongjin Pan: Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Yunzhu Yang: Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Aihua Nong: Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Zhenzhou Tang: Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
Qing X. Li: Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, 1955 East-West Road, Honolulu, HI 96822, USA

IJERPH, 2022, vol. 19, issue 23, 1-17

Abstract: Glucose-regulated protein 78 (GRP78), a molecular chaperone, is overexpressed in patients suffering from obesity, fatty liver, hyperlipidemia and diabetes. GRP78, therefore, can be not only a biomarker to predict the progression and prognosis of obesity and metabolic diseases but also a potential therapeutic target for anti-obesity treatment. In this paper, GRP78 inhibitors targeting its ATPase domain have been reviewed. Small molecules and proteins that directly bind GRP78 have been described. Putative mechanisms of GRP78 in regulating lipid metabolism were also summarized so as to investigate the role of GRP78 in obesity and other related diseases and provide a theoretical basis for the development and design of anti-obesity drugs targeting GRP78.

Keywords: GRP78; molecular target; action mechanism; metabolic disorder; obese (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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