Serum Levels of CXCR4, SDF-1, MCP-1, NF-κB and ERK1/2 in Patients with Skeletal Fluorosis

Yaqian Zhao, Guanglan Pu, Yanan Li, Hong Jiang, Qiang Zhang (), Ping Chen, Qing Lu, Mingjun Wang and Rui Yang
Additional contact information
Yaqian Zhao: Department of Public Health, Medical College, Qinghai University, Xi’ning 810016, China
Guanglan Pu: Department of Endemic Disease Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control, Xi’ning 811602, China
Yanan Li: Department of Endemic Disease Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control, Xi’ning 811602, China
Hong Jiang: Department of Endemic Disease Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control, Xi’ning 811602, China
Qiang Zhang: Department of Public Health, Medical College, Qinghai University, Xi’ning 810016, China
Ping Chen: Department of Endemic Disease Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control, Xi’ning 811602, China
Qing Lu: Department of Endemic Disease Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control, Xi’ning 811602, China
Mingjun Wang: Department of Endemic Disease Prevention and Control, Qinghai Institute for Endemic Disease Prevention and Control, Xi’ning 811602, China
Rui Yang: Department of Public Health, Medical College, Qinghai University, Xi’ning 810016, China

IJERPH, 2022, vol. 19, issue 24, 1-23

Abstract: C-X-C motif chemokine receptor 4 (CXCR4), stromal cell-derived factor-1 (SDF-1), monocyte chemoattractant protein-1 (MCP-1), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) affect bone cells and play an important role in bone and joint diseases, but the data on CXCR4, SDF-1, MCP-1, ERK1/2 and NF-κB in the serum of skeletal fluorosis (SF) patients are inconclusive. Thus, according to the “Diagnostic Criteria for Endemic Skeletal Fluorosis” (WS 192-2008), we enrolled patients with SF ( n = 60) as the SF group and those without SF as the controls ( n = 60). Serum levels of CXCR4, SDF-1, MCP-1, ERK1/2 and NF-κB were detected by enzyme-linked immunosorbent assays (ELISAs). Serum SDF-1, CXCR4, MCP-1 and NF-κB levels were significantly higher in the SF group than in the control group. Within the serum of SF patients, CXCR4 and SDF-1 levels were positively correlated with NF-κB levels. There was no correlation between MCP-1 levels and those of ERK1/2 or NF-κB. SDF-1 and CXCR4 may activate the NF-κB pathway, and MCP-1 affects the occurrence and development of SF by regulating osteocytes through other pathways. The SDF-1/CXCR4 axis and MCP-1 signalling pathway provide a new theoretical basis for the occurrence and development of SF.

Keywords: skeletal fluorosis; chemokines; extracellular signal-regulated kinase 1/2; nuclear factor-?B (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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