High Resistance to Antibiotics Recommended in Standard Treatment Guidelines in Ghana: A Cross-Sectional Study of Antimicrobial Resistance Patterns in Patients with Urinary Tract Infections between 2017–2021

Benjamin Asamoah (), Appiah-Korang Labi, Himanshu A. Gupte, Hayk Davtyan, Georgette Marfo Peprah, Forster Adu-Gyan, Divya Nair, Karlos Muradyan, Nasreen S. Jessani and Paul Sekyere-Nyantakyi
Additional contact information
Benjamin Asamoah: MDS-Lancet Laboratories, Accra P.O. Box AC 533, Ghana
Appiah-Korang Labi: World Health Organization, Country Office, Accra P.O. Box MB 142, Ghana
Himanshu A. Gupte: Narotam Sekhsaria Foundation, Mumbai 4000 021, India
Hayk Davtyan: Tuberculosis Research and Prevention Center, Yerevan 0014, Armenia
Georgette Marfo Peprah: MDS-Lancet Laboratories, Accra P.O. Box AC 533, Ghana
Forster Adu-Gyan: MDS-Lancet Laboratories, Accra P.O. Box AC 533, Ghana
Divya Nair: International Union Against TB and Lung Disease (The Union), 75006 Paris, France
Karlos Muradyan: Tuberculosis Research and Prevention Center, Yerevan 0014, Armenia
Nasreen S. Jessani: Centre for Evidence based Health Care, Department of Global Health, Stellenbosch University, Cape Town 800, South Africa
Paul Sekyere-Nyantakyi: MDS-Lancet Laboratories, Accra P.O. Box AC 533, Ghana

IJERPH, 2022, vol. 19, issue 24, 1-12

Abstract: Management of urinary tract infections is challenged by increasing antimicrobial resistance (AMR) worldwide. In this study, we describe the trends in antimicrobial resistance of uropathogens isolated from the largest private sector laboratory in Ghana over a five-year period. We reviewed positive urine cultures at the MDS Lancet Laboratories from 2017 to 2021. The proportions of uropathogens with antimicrobial resistance to oral and parenteral antimicrobials recommended by the Ghana standard treatment guidelines were determined. The proportion of multi-drug resistant isolates, ESBL and carbapenemase-producing phenotypes were determined. Of 94,134 urine specimens submitted for culture, 20,010 (22.1%) were culture positive. Enterobacterales was the most common group of organisms, E. coli (70.6%) being the most common isolate and Enterococcus spp. the most common gram-positive (1.3%) organisms. Among oral antimicrobials, the highest resistance was observed to ciprofloxacin (62.3%) and cefuroxime (60.2%) and the least resistance to fosfomycin (1.9%). The least resistance among parenteral antimicrobials was to meropenem (0.3%). The highest multi-drug resistance levels were observed among Klebsiella spp. (68.6%) and E. coli (64.0%). Extended-spectrum beta-lactamase (ESBL) positivity was highest in Klebsiella spp. (58.6%) and E. coli (50.0%). There may be a need to review the Ghana standard treatment guidelines to reflect increased resistance among uropathogens to recommended antimicrobials.

Keywords: urinary tract infection; Ghana; antimicrobial resistance (AMR); multi-drug resistance (MDR); MDS Lancet Laboratories; Access, Watch and Reserve (AWaRE) classification; uropathogens (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/24/16556/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/24/16556/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:24:p:16556-:d:998609

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().