Primary Clear Cell Adenocarcinoma of the Uterine Cervix in a 14-Year-Old Virgin Girl: Case Report

Iuliana Elena Bujor, Ludmila Lozneanu, Alexandra Ursache (), Alexandra Cristofor, Ana-Maria Scurtu, Petru Plamadeala, Roxana Gireada, Cristina Elena Mandici, Marcel Alexandru Găină and Daniela Roxana Matasariu
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Iuliana Elena Bujor: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania
Ludmila Lozneanu: Department of Morpho-Functional Sciences I—Histology, Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Alexandra Ursache: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania
Alexandra Cristofor: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania
Ana-Maria Scurtu: Department of Pediatric Surgery, Children’s Clinical Hospital “St. Maria”, 700309 Iasi, Romania
Petru Plamadeala: Department of Pathology, Children’s Clinical Hospital “St. Maria”, 700309 Iasi, Romania
Roxana Gireada: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania
Cristina Elena Mandici: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania
Marcel Alexandru Găină: Psychiatry, Department of Medicine III, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Daniela Roxana Matasariu: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy ‘Grigore T. Popa’, 700115 Iasi, Romania

IJERPH, 2022, vol. 19, issue 24, 1-13

Abstract: Cervical cancer is rare in adolescent and pediatric populations, with adenocarcinoma being the most commonly reported. Clear cell adenocarcinoma of the uterine cervix accounts for only 4% of all adenocarcinoma cases, and about two-thirds are associated with intrauterine diethylstilbestrol (DES) exposure. We report the case of a 14-year-old virgin girl who presented with a 1-month-long history of abnormal vaginal bleeding and lower abdominal pain. Transabdominal pelvic ultrasound examination revealed the presence of an irregular, homogeneous cervical mass that was 7 cm in size. Therefore, a magnetic resonance imaging (MRI) scan was performed to establish the origin of the tumor and its relationship to adjacent pelvic organs. Furthermore, a vaginoscopy was performed to identify the tumor, and a cervical biopsy was performed. Immunohistochemical and anatomopathological studies resulted in the diagnosis of non-HPV(Human Papilloma Virus)-related clear cell adenocarcinoma of the cervix. Following the oncological examination, she was admitted for radiotherapy. The patient had no maternal history of DES exposure in utero. Even though the number of cases in the literature is low, most of the virgin girls diagnosed with clear cell adenocarcinoma of the cervix have a fatal prognosis because of the delay in making a correct diagnosis.

Keywords: clear cell adenocarcinoma; virgin girl; non-HPV; diethylstilbestrol; radiotherapy; chemotherapy; intracavitary brachytherapy; immunohistochemical (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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