Simultaneous Determination for Nine Kinds of N-Nitrosamines Compounds in Groundwater by Ultra-High-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry

Shanshan Chen, Yi Zhang, Qinghua Zhao, Yaodi Liu and Yun Wang ()
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Shanshan Chen: School of Environment, Tsinghua University, No. 30 Shuangqing Road, Hai Dian District, Beijing 100084, China
Yi Zhang: SHANGHAI Soong Ching Ling School, Shanghai 200000, China
Qinghua Zhao: Physics, Tibet University, No. 10 Zangda East Road, Lhasa 850000, China
Yaodi Liu: Physics, Tibet University, No. 10 Zangda East Road, Lhasa 850000, China
Yun Wang: School of Water Resources and Environmental Engineering, Nanyang Normal University, No. 1398 Wolong Road, Nanyang 473061, China

IJERPH, 2022, vol. 19, issue 24, 1-11

Abstract: The ability to effectively detect N-nitrosamine compounds by liquid chromatography–tandem mass spectrometry presents a challenge due to the problems of high detection limits and difficulty in simultaneous N-nitrosamine compound detection. In order to overcome these limitations, this study reduced the detection limit of N-nitrosamine compounds by applying n-hexane pre-treatment to remove non-polar impurities before the conventional process of column extraction. In addition, ammonium acetate was used as the mobile phase to enhance the retention of nitrosamine target substances on the chromatographic column, with formic acid added to the mobile phase to improve the ionization level of N-nitrosodiphenylamine, to achieve the simultaneous detection of multiple N-nitrosamine compounds. Applying these modifications to the established detection method allowed the rapid and accurate detection of N-nitrosamine in water within 12 min. The linear relationship, detection limit, quantification limit and sample spiked recovery rate of nine types of nitrosamine compound were investigated, showing that the correlation coefficient ranged from 0.9985–0.9999, while the detection limits of the instrument and the method were 0.280–0.928 µg·L −1 and 1.12–3.71 ng·L −1 , respectively. The spiked sample recovery rate ranged from 64.2–83.0%, with a standard deviation of 2.07–8.52%, meeting the requirements for trace analysis. The method was applied to the detection of N-nitrosamine compounds in nine groundwater samples in Wuhan, China, and showed that the concentrations of N-nitrosodimethylamine and NDEA were relatively high, highlighting the need to monitor water bodies with very low levels of pollutants and identify those requiring treatment.

Keywords: groundwater; solid phase extraction (SPE); ultra-high performance liquid chromatography triple quadrupole instrument (UHPLC-MS/MS); n-nitrosamine compounds (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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