Association between Perceived Health-Related Quality of Life and Depression with Frailty in the FRASNET Study

Giulia B. Delli Zotti, Lorena Citterio, Sara Farinone, Maria Pina Concas, Elena Brioni, Laura Zagato, Elisabetta Messaggio, Sipontina Faienza, Marco Simonini, Alessandra Napoli, Valentina Di Mattei, Patrizia Rovere-Querini, Lucio Sarno, Emilio Clementi, Angelo A. Manfredi, Chiara Lanzani () and Paolo Manunta
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Giulia B. Delli Zotti: Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Lorena Citterio: Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Sara Farinone: Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Maria Pina Concas: Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
Elena Brioni: Nephrology Operative Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
Laura Zagato: Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Elisabetta Messaggio: Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Sipontina Faienza: Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Marco Simonini: Nephrology Operative Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
Alessandra Napoli: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, Università di Milano, 20122 Milan, Italy
Valentina Di Mattei: Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Patrizia Rovere-Querini: Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy
Lucio Sarno: Clinical and Health Psychology Unit, IRCCS San Raffaele Scientific Institute, School of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy
Emilio Clementi: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, Università di Milano, 20122 Milan, Italy
Angelo A. Manfredi: Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy
Chiara Lanzani: Nephrology Operative Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
Paolo Manunta: Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, School of Nephrology, Vita-Salute San Raffaele University, 20132 Milan, Italy

IJERPH, 2022, vol. 19, issue 24, 1-18

Abstract: Frailty is a major challenge facing the aging world. The phenotype of the frail subject is still far from being satisfactorily defined. We report data on mood, cognition, and quality of life (QoL) in relation to anamnestic factors, health, and socio-economic status in the FRASNET geriatric population (1204 subjects in stable health conditions), which is an observational cohort study that includes fairly balanced groups of Italian frail (421, 35%), pre-frail (449, 37.3%) and robust (334, 27.7%) subjects. A conditional inference tree analysis revealed a substantial influence of psychological variables on frailty. The physical indicator of QoL (Short Form Survey-36-Physical Component Summary, SF-36-PCS) was the predominant variable in the full model (threshold at 39.9, p < 0.001): higher frailty was found in subjects with a caregiver and lower SF-36-PCS. Frailty was also associated with the mental indicator of QoL (Short Form Survey-36-Mental Component Summary, SF-36-MCS), depression (Geriatric Depression Scale, GDS-15), leisure activities, and level of education. In support of the prominent role of inflammation in aging and mental illness, the SF-36-PCS score was correlated with the blood concentration of C-X-C motif chemokine ligand 10 (CXCL10) (r Pearson −0.355, p = 0.015), a critical signal in cell senescence and inflammaging, while the rs7567647 variant in FN1 gene encoding a glycoprotein in the extracellular matrix was significantly associated with frailty in a multivariable model ( p = 0.0006). The perception of health-related QoL and subclinical depression contribute to frailty. Their assessment could improve the identification of older patients at increased risk of adverse outcomes.

Keywords: frailty; aging; quality of life; inflammation; genetics; multidimensional model (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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