Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in Touba, Senegal

Idrissa Dieng (), Cheikh Fall, Mamadou Aliou Barry, Aboubacry Gaye, Ndongo Dia, Marie Henriette Dior Ndione, Amary Fall, Mamadou Diop, Fatoumata Diene Sarr, Oumar Ndiaye, Mamadou Dieng, Boly Diop, Cheikh Tidiane Diagne, Mamadou Ndiaye, Gamou Fall, Mbacké Sylla, Ousmane Faye, Cheikh Loucoubar, Oumar Faye and Amadou Alpha Sall
Additional contact information
Idrissa Dieng: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Cheikh Fall: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Mamadou Aliou Barry: Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Aboubacry Gaye: Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Ndongo Dia: Respiratory Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Marie Henriette Dior Ndione: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Amary Fall: Respiratory Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Mamadou Diop: Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Fatoumata Diene Sarr: Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Oumar Ndiaye: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Mamadou Dieng: Ministry of Health, Dakar 16504, Senegal
Boly Diop: Ministry of Health, Dakar 16504, Senegal
Cheikh Tidiane Diagne: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Mamadou Ndiaye: Ministry of Health, Dakar 16504, Senegal
Gamou Fall: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Mbacké Sylla: Ministry of Health, Dakar 16504, Senegal
Ousmane Faye: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Cheikh Loucoubar: Epidemiology, Clinical Research and Data Science Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Oumar Faye: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal
Amadou Alpha Sall: Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar 220, Senegal

IJERPH, 2022, vol. 19, issue 24, 1-13

Abstract: Dengue virus (DENV) was detected in Senegal in 1979 for the first time. Since 2017, unprecedented frequent outbreaks of DENV were noticed yearly. In this context, epidemiological and molecular evolution data are paramount to decipher the virus diffusion route. In the current study, we focused on a dengue outbreak which occurred in Senegal in 2018 in the context of a large religious gathering with 263 confirmed DENV cases out of 832 collected samples, including 25 life-threatening cases and 2 deaths. It was characterized by a co-circulation of dengue serotypes 1 and 3. Phylogenetic analysis based on the E gene revealed that the main detected serotype in Touba was DENV-3 and belonged to Genotype III. Bayesian phylogeographic analysis was performed and suggested one viral introduction around 2017.07 (95% HPD = 2016.61–2017.57) followed by cryptic circulation before the identification of the first case on 1 October 2018. DENV-3 strains are phylogenetically related, with strong phylogenetic links between strains retrieved from Burkina Faso and other West African countries. These phylogenetic data substantiate epidemiological data of the origin of DENV-3 and its spread between African countries and subsequent diffusion after religious mass events. The study also highlighted the usefulness of a mobile laboratory during the outbreak response, allowing rapid diagnosis and resulting in improved patient management.

Keywords: dengue virus 3; re-emergence; genotype III; Senegal; 2018; mass gathering; mobile laboratory (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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